2012 ©
             Publication
Journal Publication
Title of Article Combined Effect of Subchondral Drilling and Hyaluronic Acid with/without Diacerein in Full-Thickness Articular Cartilage Lesion in Rabbits  
Date of Acceptance 21 December 2011 
Journal
     Title of Journal The Scientific World Journal 
     Standard  
     Institute of Journal The Scientific World Journal 
     ISBN/ISSN  
     Volume 2012 
     Issue 2012 
     Month -
     Year of Publication 2012 
     Page doi:10.1100/2012/310745 
     Abstract The osteochondral healing potential of hyaluronic acid (HA) plus diacerein was evaluated in subchondral-drilling- (SCD-) induced fibrocartilage generation in rabbits. A full-thickness chondral defect was created along the patellar groove of both knees and then SCD was subsequently performed only in the left knee. A week later, the rabbits were allocated into 3 groups to receive weekly intra-articular (IA) injection for 5 weeks with normal saline solution (NSS) (group 1) or with HA (group 2 and group 3). Starting at the first IA injection, rabbits were also gavaged daily for 9 weeks with NSS (group 1 and group 2) or with diacerein (group 3). The animals were then sacrificed for evaluation. The newly formed tissue in SCD lesions showed significantly better histological grading scale and had higher content of type II collagen in HA-treated group compared to NSS control. In addition, adding oral diacerein to HA injection enhanced healing potential of HA. 
     Keyword Diacerein, Hyaluronic acid, Osteoarthritis, Subchondral drilling 
Author
517070017-6 Miss WANWISA SUWANNALOET [Main Author]
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
citation false 
Part of thesis true 
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