2012 ©
             Publication
Journal Publication
Title of Article HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status 
Date of Acceptance 11 March 2014 
Journal
     Title of Journal Biochemical and Biophysical Research Communications 
     Standard  
     Institute of Journal Elsevier 
     ISBN/ISSN ISSN: 0006-291X 
     Volume 2014 
     Issue  
     Month March
     Year of Publication 2014 
     Page  
     Abstract The balance between active immune responses against human papillomavirus (HPV) and HPV-induced immune escape regulates viral clearance and carcinogenesis. To understand the role of the early viral protein HPV16 E2 in host innate immune responses, the HPV16 E2-transfected murine squamous cell carcinoma cell line SCCVII (SCC/E2) was generated and anti-tumor responses in T-cell-depleted mice were evaluated. Tumor growth of SCC/E2 was markedly reduced. Cytotoxicity against the NK-sensitive targets YAC-1 and SCCVII was clearly enhanced in SCC/E2-inoculated mice. Despite the comparable ratio of NK cells, the proportion of CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) was significantly decreased in SCC/E2-inoculated mice. The transcription of MDSC-related mediators such as inducible nitric oxide synthase, indoleamine 2,3-dioxygenase, and heme oxygenase-1 was significantly impaired in the SCC/E2-inoculated tumor tissues on day 3. Our results suggest that HPV16 E2 promotes anti-tumor innate effector function by modulating immunoregulatory events mediated by MDSCs and their mediators. This report describes a new role for HPV16 E2 as a local immunomodulator at infected sites. 
     Keyword Human papillomavirus, NK cells, Myeloid-derived suppressor cells, Immunosuppression 
Author
517070001-1 Miss NUCHSUPHA SUNTHAMALA [Main Author]
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
citation true 
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