| Research Title |
Garcinia mangostana pericarp extract alleviates hypertension via oxidative stress reduction and normalizes cardiac hypertrophy in L-NAME-induced hypertensive rats |
| Date of Distribution |
27 March 2015 |
| Conference |
| Title of the Conference |
การประชุมวิชาการนำเสนอผลงานวิจัย ระดับบัณฑิตศึกษาแห่งชาติ ครั้งที่ 34 |
| Organiser |
บัณฑิตวิทยาลัย มหาวิทยาลัยขอนแก่น |
| Conference Place |
อาคารเรียนรวม คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| Province/State |
ขอนแก่น |
| Conference Date |
27 March 2015 |
| To |
27 March 2015 |
| Proceeding Paper |
| Volume |
2015 |
| Issue |
34 |
| Page |
64-73 |
| Editors/edition/publisher |
|
| Abstract |
Garcinia mangostana (mangosteen), a xanthone derivative, one class of polyphenolic compounds which were shown to be a potent benefit for antioxidant property. The aim of this study was to investigate the preventive effect of mangosteen pericarp extract on systolic blood pressure (SBP), oxidative stress markers and cardiac wall
dimension in nitric oxide-deficient hypertensive rats. Male Sprague-Dawley rats were given N-nitro-L-arginine methyl ester (L-NAME) in drinking water to induce hypertension, and simultaneously treated with mangosteen pericarp extract (L-NAME+Mag group). Age-matched rats served as a control group and normotensive treated with mangosteen pericarp extract (Control+Mag group). We found that SBP, superoxide production, and plasma
malondialdehyde level in L-NAME+Mag rats was significantly lower than those in L-NAME which is corresponding to an increase in ventricular luminal area (p<0.05). In conclusion, mangosteen pericarp extract has antihypertensive property and improved cardiac wall remodeling in L-NAME-induced hypertensive model. |
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
|
Publication
Journal Publication
ไทย