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Publication
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| Research Title |
A Feasibility Study of Microwave-Treated Glutinous Rice Starch for Disintegrant
in Direct Compressed Tablet |
| Date of Distribution |
28 June 2018 |
| Conference |
| Title of the Conference |
The 8th National and International Graduate Study Conference (NGSC&IGSC 2018) |
| Organiser |
The Graduate school, Silpakorn University |
| Conference Place |
Princess Maha Chakri Sirindhon Anthropology Centre |
| Province/State |
Bangkok |
| Conference Date |
28 June 2018 |
| To |
29 June 2018 |
| Proceeding Paper |
| Volume |
2018 |
| Issue |
1 |
| Page |
I14-I22 |
| Editors/edition/publisher |
The Graduate school, Silpakorn University |
| Abstract |
The formulation of fast released tablet is necessary to use disintegrant for enhancing
disintegration of tablet. Typically, the mechanism of disintegrant such as pregelatinized
starch (PS, Starch 1500®) , sodium starch glycolate (SSG, Explotab®) as well as
microwave treated glutinous rice starch ( MGS) is mainly swelling. The objective of
this study was to investigate the MGS properties and the effect of MGS on the
properties of direct compressed tablet. Each tablet was consisted of di-basic calcium
phosphate (DCP) as a filler, MGS (0-10% w/w) and magnesium stearate (2% w/w) as
a lubricant. Properties of tablets using MGS, PS and SSG as disintegrant were
evaluated. The FTIR spectra showed that the chemical structure of MGS was changed,
and no endothermic peak at 25- 100 oC was observed. Swelling capacity and viscosity
of MGS were directly dependent on a type of medium. When increasing the
concentration of MGS, tablet weight and thickness were increased accordingly.
Interestingly, the tablet containing 0 - 4 % w/w of MGS, disintegration time of tablet
was significantly decreased ( p<0. 05) . Nevertheless, the increasing of MGS ( 6-10
% w/w) , hardness and disintegration time of tablets were significantly increased ( p <
0.05). At 4 %w/w of disintegrant, the disintegration time of tablets were ranging as GS
> MGS> PS > SSG. From the results, it can be concluded that MGS has the potential
to use as disintegrant in direct compressed tablet. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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