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Publication
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| Research Title |
Microalbuminuria detection: comparisons of two differently semiquantitative urine strip tests with a quantitative automated chemistry analyzer |
| Date of Distribution |
21 May 2019 |
| Conference |
| Title of the Conference |
23rd IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine ( IFCC-EFLM EuroMedLab Barcelona 2019 Congress) |
| Organiser |
International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), European Federation of Laboratory Medicine (EFLM) and the Spanish Society of Laboratory Medicine |
| Conference Place |
CCIB - CENTRE CONVENCIONS INTERNACIONAL DE BARCELONA |
| Province/State |
Barcelona, Spain |
| Conference Date |
19 May 2019 |
| To |
23 May 2019 |
| Proceeding Paper |
| Volume |
493S1 (June 2019) |
| Issue |
Special issue |
| Page |
S460–S492 |
| Editors/edition/publisher |
Joris Delanghe, University Hospital Gent, Gent, Belgium Alan H. Wu, San Francisco General Hospital, San Francisco, CA, USA |
| Abstract |
Background-aim
Microalbuminuria is a marker of early kidney disease and an
independent risk factor for atherosclerotic diseases. Nowadays,
albuminuria detection in routine urinalysis is mainly screening test
for macroalbuminuria or proteinuria. It is not an optimal screening
test for microalbuminuria although the most of protein strip tests
include some levels of microalbuminuria. Thus, we aimed to compare
the detection of microalbuminuria by using new semiquantitative
URiSCAN 2 ACR strip test and routine protein strip test with
quantitative automated chemistry analyzer.
Methods
Total of 530 spot urine specimens of volunteers in CKDNET
project were enrolled in the study. All specimens were analyzed
quantitative levels of microalbumin and creatinine by using the
SYNCHRON Lx20 PRO automated chemistry analyzer, analyzed
semiquantitative levels of microabuminuria by using the URiSCAN 2
Optima urine chemistry test system, and analyzed semiquantitative
levels of proteinuria with one level of microalbuminuria by using the
iChem VELOCITY system in routine urinalysis.
Results
The effectiveness of URiSCAN 2 ACR strip test for microalbuminuria detection was 92.9% of sensitivity, 58.7% of specificity
and 64.2% of accuracy. The false positive and the false negative rates
were 41.3% and 7.1%, respectively. An agreement of URiSCAN 2 ACR
strip test and the iChem VELOCITY protein strip test with automated
chemistry analyzer were 60.6% and 70.4%, respectively, sensitivities
of those methods were 92.9% and 89.4%, respectively, and specificities of those methods were 54.4% and 66.7%, respectively.
Conclusions
Based on high sensitivity and low negative rate of the test,
URiSCAN 2 ACR strip test could be used as an alternative screening
test for detection of microalbuminuria. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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