| Research Title |
EFFECTS OF Stephania venosa TUBER EXTRACTS ON CHOLANGIOCARCINOMA CELL LINES |
| Date of Distribution |
20 October 2012 |
| Conference |
| Title of the Conference |
The 5th Thailand-Japan International Academic Conference 2012 |
| Organiser |
Thai Studens' Association in Japan under the Royal Patronage (TSAJ) |
| Conference Place |
Tokyo Institute of Technology |
| Province/State |
Tokyo |
| Conference Date |
20 October 2012 |
| To |
20 October 2012 |
| Proceeding Paper |
| Volume |
5 |
| Issue |
1 |
| Page |
149-150 |
| Editors/edition/publisher |
|
| Abstract |
Cholangiocarcinoma is an aggressive tumor of bile duct epithelium for which a standard effective treatment is unavailable. In this study, the cytotoxic effect of the crude ethyl acetate (EtOAc) and methanol (MeOH) extracts of Stephania venosa tubers in human CCA cell lines were investigated. The EtOAc extract exhibited cytotoxicity against KKU–M139, KKU–M213 and KKU–M214 cells with IC50 values of 15.68 ± 0.23, 11.79 ± 0.37 and 7.50 ± 0.42 μg /mL, respectively. The MeOH extract exhibited cytotoxicity against KKU-M139, KKU–M213 and KKU–M214 with IC50 values of 7.25 ± 0.34, 9.28 ± 1.0 and 0.61 ± 0.15 μg /mL, respectively. Chromatographic separation of these crude extracts yielded 5 compounds. Their
structures were identified by spectroscopic mean to primary conclude as alkaloid type. These compounds thus, hold the promise of being a potent anticancer agent that deserved further exploration. |
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Oral |
| Part of thesis |
false |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
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Publication
Journal Publication
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