| Research Title |
Berberine modified sex hormone synthesis related genes in mouse testes |
| Date of Distribution |
22 November 2012 |
| Conference |
| Title of the Conference |
The 1st International Conference on Health Science, Thai Traditional and Alternative Medicine (ICHTAM) : The Role of Traditional / Alternative Medicine Health Care |
| Organiser |
Faculty of Medicine Mahasarakham University, WHO/SEARO |
| Conference Place |
Convention Hall, Taksila Hotel, Mahasarakham, Thailand |
| Province/State |
Mahasarakham |
| Conference Date |
21 November 2012 |
| To |
23 November 2012 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
56 |
| Editors/edition/publisher |
- |
| Abstract |
Berberine has been traditionally used for the treatment of diabetes mellitus. Many studies have shown hypoglycemic activity of berberine. However, its impact on sex hormone synthesis pathway is still less. The present study aims to investigate effect of berberine on the expression of sex hormone synthesis related genes in β-naphthoflavone (BNF)-exposed mouse testes. Adult male C57BL/6Mlac mice were consecutively intragastric administered berberine (7.5 mg/kg/d) for 7 day, and/or intraperitoneally injected BNF (30 mg/kg/d) for the last 3 days. Expression of testicular CYP17, CYP19, 3β-HSD1, 17β-HSD3, and 17β-HSD1 mRNAs were semi-quantified by RT-PCR. Berberine significantly up-regulated the expression of CYP17, 3β-HSD1, and 17β-HSD1 mRNA while BNF markedly induced the expression of 17β-HSD1 mRNA. Regarding to the BNF-exposure, berberine reduced 17β-HSD1 mRNA to nearly the same level as the normal whereas those of CYP17 and 3β-HSD1 were as high as that did by berberine itself. These observations suggested that berberine disturbed sex hormone synthesis pathway; consequently possibly resulted in modification of estrogen pattern in the body. Therefore, a caution is noted for the use of berberine as an alternative medicine and a further study to affirm the evidence in the DM status is worth. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
The consolation oral presentation award |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
Faculty of Medicine Mahasarakham University |
| Date of awarding |
23 พฤศจิกายน 2555 |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย