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Publication
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| Research Title |
Evaluation of clinical scoring systems for systemic inflammation in adult patients undergoing cardiac surgery with related to inflammatory cytokine levels |
| Date of Distribution |
28 May 2011 |
| Conference |
| Title of the Conference |
ASCVTS-ATCSA 2011 Joint Meeting of 19thASCVTS and 21stATCSA and 4th AATS/ASCVTS Postgraduate Course |
| Organiser |
The society of Thoracic Surgeons of Thailand and The American Association for Thoracic Surgery |
| Conference Place |
Phuket, Thailand |
| Province/State |
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| Conference Date |
26 May 2011 |
| To |
29 May 2011 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
- |
| Editors/edition/publisher |
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| Abstract |
Objective:
To evaluate varieties of clinical scoring systems in intra- and early post-operative cardiac surgery with cardiopulmonary bypass (CPB) and clinical outcome in relation to inflammatory cytokine levels. This correlation might identify the peri-operative clinical outcome and then forecast further systemic inflammation in cardiac surgical patients.
Method:
Design: Prospective observational study
Setting: Queen Sirikit Heart Center of the Northeast, Khon Kaen University, Thailand
Patients: Eleven consecutive adult patients who had undergone elective cardiac surgery with cardiopulmonary bypass (CPB) were enrolled in this study.
Interventions: None
Measurement: Parameters for the modified APACHE II, SOFA and MOD scoring systems were collected before, during and early post-operative periods. In addition, blood samples were collected at pre-operation and sequentially at 0, 0.5, 4, 12, and 24 hours post-operation for cytokines (IL-6, IL-8, and IL-10) and leukocyte counts (neutrophils, lymphocytes, and monocytes).
Result:
The outcomes of the modified APACHE II, SOFA, and MOD scores were similar. However, IL-6 and IL-8 levels rose at 4 hours after CPB then decreased slightly at 24 hours while the IL-10 levels rapidly returned to near normal level in all patients. While absolute neutrophil counts showed similar patterns at all time-points, the correlations of inflammatory cytokines and all modified scores were comparable. Interestingly, the correlation of IL-6 and modified SOFA score was better at 24 hours after the CPB.
Conclusion:
All the scoring systems for SIRS could be used in patients undergoing cardiac surgery with CPB. The modified SOFA score which is simpler than the other scoring systems might be a good indicator to predict a serious outcome after cardiac surgery.
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย