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Publication
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| Title of Article |
HPV16 E2 protein promotes innate immunity by modulating immunosuppressive status |
| Date of Acceptance |
11 March 2014 |
| Journal |
| Title of Journal |
Biochemical and Biophysical Research Communications |
| Standard |
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| Institute of Journal |
Elsevier |
| ISBN/ISSN |
ISSN: 0006-291X |
| Volume |
2014 |
| Issue |
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| Month |
March |
| Year of Publication |
2014 |
| Page |
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| Abstract |
The balance between active immune responses against human papillomavirus (HPV) and HPV-induced
immune escape regulates viral clearance and carcinogenesis. To understand the role of the early viral protein
HPV16 E2 in host innate immune responses, the HPV16 E2-transfected murine squamous cell carcinoma
cell line SCCVII (SCC/E2) was generated and anti-tumor responses in T-cell-depleted mice were
evaluated. Tumor growth of SCC/E2 was markedly reduced. Cytotoxicity against the NK-sensitive targets
YAC-1 and SCCVII was clearly enhanced in SCC/E2-inoculated mice. Despite the comparable ratio of NK
cells, the proportion of CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) was significantly
decreased in SCC/E2-inoculated mice. The transcription of MDSC-related mediators such as inducible
nitric oxide synthase, indoleamine 2,3-dioxygenase, and heme oxygenase-1 was significantly impaired
in the SCC/E2-inoculated tumor tissues on day 3. Our results suggest that HPV16 E2 promotes anti-tumor
innate effector function by modulating immunoregulatory events mediated by MDSCs and their mediators.
This report describes a new role for HPV16 E2 as a local immunomodulator at infected sites. |
| Keyword |
Human papillomavirus, NK cells, Myeloid-derived suppressor cells, Immunosuppression |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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