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ข้อมูลการเผยแพร่ผลงาน
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| ชื่อบทความที่เผยแพร่ |
Patient and doctor reporting of ADR to Methylphenidate in treatment of attention deficit hyperactivity disorders at a university hospital. (ไม่ผ่านการอนุมัติ 1399903882) |
| วัน/เดือน/ปี ที่เผยแพร่ |
8 เมษายน 2557 |
| การประชุม |
| ชื่อการประชุม |
International Forum on Quality and Safety in Healthcare 2014 |
| หน่วยงาน/องค์กรที่จัดประชุม |
BMJ Group Ltd, UK |
| สถานที่จัดประชุม |
Palais les congres |
| จังหวัด/รัฐ |
ปารีส ฝรั่งเศส |
| ช่วงวันที่จัดประชุม |
8 เมษายน 2557 |
| ถึง |
11 เมษายน 2557 |
| Proceeding Paper |
| Volume (ปีที่) |
2014 |
| Issue (เล่มที่) |
- |
| หน้าที่พิมพ์ |
- |
| Editors/edition/publisher |
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| บทคัดย่อ |
Background Methylphenidate (MPH) is the main drug used in ADHD requiring long term treatment which consequently may cause serious adverse drug reactions (ADRs). Patient reporting is a feasible source of ADR monitoring however such information in children is still be needed to investigate in Thailand. Purpose To determine the frequency of ADRs to MPH by comparing the reports of patients and doctors in the frequency and severity of symptoms and to evaluate factors related to a number of symptoms reported. Materials and Methods The data were obtained from outpatients who were taking MPH which were prescribed during June 12, 2013 - September 12, 2013 at Srinagarind Hospital. Patients and/or their parents were asked to report patients’ conditions by using symptom checklist questionnaires. The questionnaires were distributed to patients directly at the outpatient clinic. All symptoms reported were classified, taking into account information provided by patients and outpatient department (OPD) cards on their concomitant drugs and diseases. Doctors’ reports of ADRs were obtained from chart reviews. Results Of the total 644 questionnaires distributed, 644 responded (100%) consisted of 620 (96.0%) answered by parents and 24 (4.0%) by patients. There were 604 (93.8%) valid responses obtained plus 40 responses considered invalid, due to lack of completion, failure to take the prescribed index drug and missing of OPD cards. The majority of respondents were female (52.2%), with mean age of 40.30 + 7.73 years and the common education level was bachelor’s degree (88.9%). Most patients in this study were male (87.7%) with mean age of 9.37 + 2.96 years. The median number of duration for MPH therapy was 730 days (range 101 to 3321 days). Of the total 604 respondents, 508 (84.1%) reported at least one symptom. Adverse symptoms affecting gastrointestinal system (60.2% of total symptoms reported) were most common reported by patients. The top five symptoms that had bothered patients’ lifestyle were appetite decrease (45.7%), constipation (16.0%), headache (14.6%), insomnia (12.0%) and nausea (11.7%) respectively. Most patients reported the severity of the symptom in moderate level (54.9%). The source of information that most patients used to confirm their ADRs was drug leaflets (53.6%) followed by internet (30.3%). A high proportion of patients (67.1%) informed doctors about all of their symptoms. It was found that doctors had recorded only 199 symptoms, which were mostly recorded as symptoms (52.8%) and less than half recorded as ADRs (44.2%). The most recorded ADRs were appetite decrease (55.7%), headache (23.9%) and insomnia (20.4%) which was correlated with patients’ reported ADRs. The factors significantly influenced a number of symptoms reported by patients were age of respondents, level of education and number of concomitant drug (p=0.018, p=0.046 and p<0.001, respectively). Conclusions This study suggests that patient reporting is a useful method in detecting and monitoring of ADRs for drugs use in a long term treatment, particularly in children. Patients reported more symptoms and their reports were concurred with doctors’ reports. Patient reporting could be incorporated with routine ADR reporting by health professionals since it can increase number of ADRs reports and serve as a warning signals for patients’ safety. |
| ผู้เขียน |
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| การประเมินบทความ (Peer Review) |
มีผู้ประเมินอิสระ |
| มีการเผยแพร่ในระดับ |
นานาชาติ |
| รูปแบบ Proceeding |
Abstract |
| รูปแบบการนำเสนอ |
Poster |
| เป็นส่วนหนึ่งของวิทยานิพนธ์ |
เป็น |
| ผลงานที่นำเสนอได้รับรางวัล |
ไม่ได้รับรางวัล |
| แนบไฟล์ |
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| Citation |
0
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