| Abstract |
Valproate (VPA) is widely used in treating for epileptic patients. However, adverse effects of VPA on male reproductive system especially testicular damages were documented. It is unclear whether VPA induction for 7 days can damage the rat testicular histology as reported from a previous study. Therefore, the present study was aimed to reinvestigate it and attempt to observe the critical days that can effectively induce rat testicular damages compared between 7 and 10 days. The Wistar rats were injected (i.p.) with normal saline or VPA (500 mg/kg BW) for 7 and 10 consecutive days and observed reproductive organ weights, testicular histology, seminiferous tubular diameter, and sperm concentration, respectively. Significantly, the results showed that VPA induction for 10 days can obviously damage testicular histology and decrease reproductive organ weights, seminiferous tubular diameter, and sperm concentration as compared with 7 days induction which is similar to that of the control. In conclusion, 10 days of VPA induction are optimum days to induce damages of reproductive organs in Wistar rats for using them as animal model. |
Publication
Journal Publication
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