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Publication
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| Research Title |
ADAMTS13 Q448E polymorphism and the risk of coronary artery disease in dyslipidemic subjects |
| Date of Distribution |
17 July 2014 |
| Conference |
| Title of the Conference |
The International Medical Sciences Conference 2014 |
| Organiser |
Faculty of Associated Medical Sciences, Khon Kaen University |
| Conference Place |
Pullman Khon Kaen Raja Orchid Hotel |
| Province/State |
Khon Kaen, Thailand |
| Conference Date |
15 July 2014 |
| To |
17 July 2014 |
| Proceeding Paper |
| Volume |
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| Issue |
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| Page |
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| Editors/edition/publisher |
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| Abstract |
ADAMTS13 Q448E polymorphism and the risk of coronary artery disease in dyslipidemic subjects
Lasom S1,2, Komanasin N2,3, Settasatian N2,3, Settasatian C2,4, Kukongviriyapan U2,4, Intharapetch P2,5, Tantipanichteerakul K5, Senthong V2,5,
1Ph.D. candidate in Biomedical Sciences Program, Graduate School, 2Cardiovascular Research Group, 3Faculty of Associated Medical Sciences, 4Faculty of Medicine, 5Queen Sirikit Heart Center of the Northeast, Khon Kaen University, Khon Kaen, Thailand, 40002
Introduction: A disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) is a von Willebrand factor cleaving protease. Low levels of ADAMTS13 are associated with arterial thrombosis, atherosclerosis progression and coronary artery disease (CAD). It has been reported that ADAMTS13 Q448E polymorphism (rs2301612) is related to reduce activity of ADAMTS13. Therefore, this study aimed to investigate the association of this polymorphism and risk of CAD in individuals with dyslipidemia.
Methods: ADAMTS13 Q448E polymorphism was analyzed in 313 dyslipidemic subjects whom were divided into 2 groups; 189 with CAD and 124 without CAD groups. The polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism technique using 2 units of Hpy188I as a restriction enzyme. CAD risk was assessed with the use of logistic regression analysis. ADAMTS13 activity level was measured by using residual collagen binding assay.
Results: The frequency of the QE+EE genotype was significantly higher in dyslipidemic subjects with CAD than those in individuals without CAD (59.8 vs 48.4%, p=0.048). After age and sex adjustment, QE+EE genotype was significantly associated with CAD risk [OR (95%CI) = 2.150 (1.082, 4.274), p=0.029]. There was no significant association between this polymorphism with other risk factors of CAD including diabetes, hypertension and obesity. Although it has been reported that Q448E polymorphism is associated with reduced ADAMTS13 activity, a significant difference of ADAMTS13 activity between QQ and QE+EE genotypes was not found in this study (72.2±19.8 vs 73.5±19.5%, p= 0.691). A relatively high proportion of hypertension in dyslipidemia with QE+EE genotype (60.0%) may partly contribute to an insignificant alteration of ADAMTS13 activity.
Conclusions: This study demonstrated that the ADAMTS13 Q448E polymorphism was associated with an increase risk of CAD in dyslipidemic individuals. However, a larger-scale of subjects is needed to confirm this association.
Key words: ADAMTS13 polymorphism, coronary artery disease, dyslipidemia
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
Best Oral Presentation |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
Faculty of Associated Medical Sciences |
| Date of awarding |
17 กรกฎาคม 2557 |
| Attach file |
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| Citation |
0
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Journal Publication
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