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Publication
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| Research Title |
The effect of anthocyanin-rich polyherbal beverage (MP1) on cognitive function, ERK1/2 expression, cholinergic function and oxidative status in ovariectomized rats. |
| Date of Distribution |
3 October 2014 |
| Conference |
| Title of the Conference |
International Scientific Acupuncture and Meridian Symposium 2014 (ISAMS 2014) |
| Organiser |
Showa University, Japan และ Korean Pharmacopuncture Institute, South Korea |
| Conference Place |
School of Medicine, Showa University |
| Province/State |
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| Conference Date |
3 October 2014 |
| To |
5 October 2014 |
| Proceeding Paper |
| Volume |
- |
| Issue |
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| Page |
- |
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| Abstract |
General description/Objectives: Excessive free radicals, hypocholinergic function and mitogen activated protein kinase (MAPK) pathway play the crucial roles on the cognitive impairment in ovariectomized rats. Based on the antioxidant, acetylcholinesterase inhibitory (AChEI) effects and the enhanced expression of extracellular signal regulated kinase (Erk1/2) MAPK of anthocyanin, the beneficial effect of anthocyanin-rich polyherbal beverage or “MP1”has gained attention. Thus, we aimed to determine the effect of “MP1” on cognitive function, ERK1/2 expression, cholinergic function and oxidative status in ovariectomized rats.
Methods: Anthocyanin-rich polyherbal beverage was produced from the extracts of Zea mays (purple waxy corn cob) and Pandanus amaryllifolius at ratio of 4:1 and it was orally given to the ovariectomized rats at doses of 20, 40 and 80 mg/kg BW for 28. Both spatial and non-spatial memory were determined every 7 days throughout the study period using Morris water maze test and Object recognition test, respectively. At the end of the study, AChE activity, ERK1/2 expression, survival neuron density and oxidative stress markers including malondialdehyde (MDA) level and the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-PX) in hippocampus and prefrontal cortex were determined.
Results: MP1 significantly improved both spatial and non-spatial memory in ovariectomized rats. The decreased oxidative stress and AChE together with the enhanced ERK1/2 expression and neuron density in hippocampus and prefrontal cortex were also observed.
Conclusion: MP1 is the potential cognitive enhancer for postmenopausal women. However, further study in clinical phase is still required.
Keywords: Anthocyanin, MP1, Ovariectomized, cognitive function, ERK1/2, oxidative status, cholinergic function
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
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