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Publication
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| Title of Article |
Anti-inflammatory and anti-periductal fibrosis effects of an anthocyanin complex in Opisthorchis viverrini-infected hamsters |
| Date of Acceptance |
29 September 2014 |
| Journal |
| Title of Journal |
Food and Chemical Toxicology |
| Standard |
ISI |
| Institute of Journal |
Elsevier |
| ISBN/ISSN |
1873-6351 |
| Volume |
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| Issue |
74 |
| Month |
October |
| Year of Publication |
2014 |
| Page |
206-215 |
| Abstract |
The pharmacological activities of herbal extracts can be enhanced by complex formation. In this study, we manipulated cyanidin and delphinidin-rich extracts to form an anthocyanin complex (AC) with turmeric
and evaluated activity against inflammation and periductal fibrosis in Opisthorchis viverriniinfected
hamsters. The AC was prepared from anthocyanins extracted from cobs of purple waxy corn (70%),
petals of blue butterfly pea (20%) and turmeric extract (10%), resulting in an enhanced free-radical scavenging
capacity. Oral administration of AC (175 and 700 mg/kg body weight) every day for 1 month to
O. viverrini-infected hamsters resulted in reduced inflammatory cells and periductal fibrosis. Fourier transform infrared spectroscopy and partial least square discriminant analysis suggested nucleic acid changes in the O. viverrini-infected liver samples, which were partially prevented by the AC treatment. AC reduced
8-oxodG formation, an oxidative DNA damagemarker, significantly decreased levels of nitrite in the plasma and alanine aminotransferase activity and increased the ferric reducing ability of plasma. AC also decreased the expression of oxidant-related genes (NF-κB and iNOS) and increased the expression of
antioxidant-related genes (CAT, SOD, and GPx). Thus, AC increases free-radical scavenging capacity, decreases
inflammation, suppresses oxidative/nitrative stress, and reduces liver injury and periductal fibrosis in O. viverrini-infected hamsters. |
| Keyword |
Anthocyanin complex, Purple waxy corn cobs, Blue butterfly pea, Curcumin, Anti-inflammatory effect, Opisthorchis viverrini |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
1
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Journal Publication
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