| Research Title |
The Effects of Streblus asper Lour. on Motor Functions in MPTP-treated C57BL/6 Mice: A Model of Parkinson’s Disease. |
| Date of Distribution |
28 May 2015 |
| Conference |
| Title of the Conference |
The 37th Congress on Pharmacology of Thailand. "Genomic Medicine and Novel Cancer Therapy: Challenges and Opportunities" |
| Organiser |
สมาคมเภสัชวิทยาแห่งประเทศไทย ร่วมกับคณะเภสัชศาสตร์ มหาวิทยาลัยอุบลราชธานี |
| Conference Place |
โรงแรมสุนีย์ แกรนด์โฮเทลแอนด์คอนเวนชั่นเซ็นเตอร์ |
| Province/State |
จ.อุบลราชธานี |
| Conference Date |
28 May 2015 |
| To |
30 May 2015 |
| Proceeding Paper |
| Volume |
2015 |
| Issue |
- |
| Page |
56 |
| Editors/edition/publisher |
|
| Abstract |
Parkinson’s disease (PD) is one of the common neurodegenerative disorders caused by degeneration of dopaminergic neurons in the substantia nigra leading to disruption of neuronal structures and/or functions. Among all the etiologies suggested to be the causes of PD, the important common mechanisms of causing neurodegeneration are oxidative damage and inflammation. Streblus asper Lour. is a medicinal plant that widely used in Thailand which has an anti-oxidative and anti-inflammatory properties. This study aimed to investigate effects of Streblus asper Lour. (SA) leaf extract on motor functions of C57BL/6 mice treated with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Animals were divided into 3 experimental groups including control, MPTP, and MPTP+SA200 groups. C57BL/6 mice were injected with 80 mg/kg MPTP (i.p.) in a 7-day period, after that the animals were tested with catalepsy (on day 3, 5, 7, and 9), beam balance (on day 5, 7, and 9) and spontaneous locomotor activity (on day 18) tests. The results showed that MPTP-treated mice had significant positive score in the catalepsy test, increase number of foot faults in beam balance, and decrease locomotor activities in activity chamber when compared to the control group. Interestingly, SA leaf extract at dose of 200 mg/kg/day (MPTP+SA200 group) could reverse MPTP-induced motor dysfunctions in all tests. Conclusion, SA leaf extract can ameliorate MPTP-induced motor dysfunctions in C57BL/6 mice. SA leaf might be useful as an additional or alternative treatment in PD. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
true |
| Award Title |
รางวัลนำเสนอผลงานประเภทโปสเตอร์ ระดับชมเชย |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
สมาคมเภสัชวิทยาแห่งประเทศไทย และ คณะเภสัชศาสตร์ มหาวิทยาลัยอุบลราชธานี |
| Date of awarding |
29 พฤษภาคม 2558 |
| Attach file |
|
| Citation |
0
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Publication
Journal Publication
ไทย