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Publication
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| Title of Article |
Asiatic Acid Reduces Blood Pressure by Enhancing Nitric Oxide Bioavailability with Modulation of eNOS and p47phox Expression in l-NAME-induced Hypertensive Rats |
| Date of Acceptance |
19 March 2014 |
| Journal |
| Title of Journal |
Phytotherapy Research |
| Standard |
ISI |
| Institute of Journal |
John Wiley & Sons, Inc. |
| ISBN/ISSN |
10 |
| Volume |
17 |
| Issue |
28 |
| Month |
March |
| Year of Publication |
2015 |
| Page |
1506-1512 |
| Abstract |
We investigated the effect of asiatic acid (AA) on hemodynamic status, vascular function, oxidative stress markers, endothelial nitric oxide synthase (eNOS), and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunit expression in Nω-nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced hypertensive rats. Male Sprague–Dawley rats treated with l-NAME (40 mg/kg/day) in drinking water for 5 weeks showed significant increases in mean arterial pressure, heart rate, hindlimb vascular resistance, vascular dysfunction, superoxide anion (O2•−) production, and plasma malondialdehyde. Moreover, NO metabolite (NOx) levels were reduced, aortic eNOS expression was downregulated, and NADPH oxidase subunit p47phox was upregulated in hypertensive rats (p < 0.05). Hypertensive rats that were administered AA (10 or 20 mg/kg/day) for the last 2 weeks of the study showed significant improvement in hemodynamic status and vascular function. The antihypertensive effects of AA were associated with elevated plasma NOx levels, together with upregulation of eNOS expression. Decreased vascular O2•− production, consistent with downregulation of p47phox expression, was also observed after AA treatment. Our results are therefore consistent with a model whereby AA reduces blood pressure by enhancing NO bioavailability. |
| Keyword |
hypertension;nitric oxide;asiatic acid;oxidative stress;vascular dysfunction |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
6
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Journal Publication
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