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Publication
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| Research Title |
Association of ABCB1 C3435T polymorphism with blood glucose levels and risk of coronary artery disease in Thais |
| Date of Distribution |
22 June 2015 |
| Conference |
| Title of the Conference |
The International Society on Thrombosis and Haemostasis 2015 Congress and 61st Annual SSC Meeting |
| Organiser |
The International Society on Thrombosis and Haemostasis |
| Conference Place |
Metro Toronto Convention Centre (MTCC) |
| Province/State |
Toronto, Ontario, Canada |
| Conference Date |
20 June 2015 |
| To |
26 June 2015 |
| Proceeding Paper |
| Volume |
13 (supplement2) |
| Issue |
- |
| Page |
292 |
| Editors/edition/publisher |
The ISTH 2015 Congress abstracts |
| Abstract |
Association of ABCB1 C3435T polymorphism with blood glucose levels and risk of coronary artery disease in Thais
Jirungda S1, 2, Komanasin N2, 3, Settasatian N2, 4, Settasatian C 2, 5, Kukongwiriyapan U2, 6, Intharapetch P2, 7, Senthong V2, 8
1Postgraduate student in Biomedical Science, Graduate School, Khon Kaen University, Khon Kaen, Thailand, 40002
2Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand, 40002
3Department of Clinical Microscopy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand, 4002
4Department of Clinical Chemistry, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand, 40002
5Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 40002
6Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 40002
7Queen Sirikit Heart Center of the Northeast Hospital, Khon Kaen University, Khon Kaen, Thailand, 40002
8Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 40002
Background: ATP-binding cassette transporter 1 (ABCB1) is a transporter protein called P-glycoprotein (P-gp) that functions as the cellular efflux for transporting a variety of substances. Previous reports have revealed that ABCB1 C3435T (rs1045642) polymorphism is associated with alteration in P-gp expression among different populations and ethnicities. Lower expression of P-gp has been proposed to reduce insulin secretion in pancreatic beta cells of rat model, which is the leading cause of type 2 diabetes mellitus (DM). Moreover, DM is in turn a risk factor for coronary artery disease (CAD).
Aims: To investigate the relationship between ABCB1 C3435T polymorphism with blood glucose levels and the risk of CAD in Thai subjects.
Methods: A total of 262 Thai subjects were enrolled in the study including 88 CAD, 63 non-CAD and 111 healthy controls. The polymorphism of ABCB1 C3435T was determined by polymerase chain reaction-restriction fragment length polymorphism techniques using 2 units of Sau3AI restriction enzyme.
Results: The genotype frequencies of CC, CT and TT genotypes between CAD and healthy controls were significantly different (37.5 vs. 24.3, 48.9 vs. 47.7 and 13.6 vs. 9.9%, respectively, p=0.024). However, this was not observed when compared those between CAD and non-CAD. Fasting blood glucose levels in CAD with TT genotype were significantly higher than those in individuals with CT and CC (p=0.001 and 0.018 respectively). Interestingly, the TT genotype revealed an increased risk for CAD compared to CC genotype in healthy controls (OR=3.1; 95% CI 1.4, 7.3; p=0.007).
Conclusion: These findings suggested that the association of the ABCB1 C3435T polymorphism with an increased risk of CAD may be modulated by its effect on blood glucose levels.
Key words: CAD, risk factor, ABCB1 gene, C3435T polymorphism, diabetes
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| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
Reach the world award |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
The International Society on Thrombosis and Haemostasis |
| Date of awarding |
22 มิถุนายน 2558 |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย