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Publication
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| Title of Article |
Positive modulation of pink Nelumbo nucifera flowers on memory impairment, brain damage and biochemical profiles in restraint rats |
| Date of Acceptance |
31 August 2015 |
| Journal |
| Title of Journal |
Oxidative Medicine and Cellular Longevity |
| Standard |
ISI |
| Institute of Journal |
Hindawi Publishing Corporation |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2015 |
| Page |
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| Abstract |
Due to the crucial role of oxidative stress on the stress-induced memory deficit, the benefit of
substance possessing antioxidant effect is focused. Since no data are available, we aimed to
determine the effect of Nelumbo nucifera flowers extract on spatial memory and hippocampal
damage in stressed rats. Male Wistar rats, weighing 250-350 g, were orally given N.nucifera
extract at doses of 10, 10 and 200 mg·kg-1 45 minutes before the exposure to 12 hourrestraint stress. The spatial memory and serum corticosterone were assessed at 7 and 14 days
of study period. At the end of study, acetylcholinesterase (AChE), monoamine oxidase type
A and B (MAO-A and B), oxidative stress status, neuron density and Ki67 expression in
hippocampus were also assessed. The results showed that N.nucifera extract decreased
memory deficit and brain damage, serum corticostrone, oxidative stress status, AChE, MAOA and B activities but increased neuron density and Ki67 expression in hippocampus. These
suggested that the improved oxidative stress status, adult neurogenesis, cholinergic and
monoaminergic functions might be responsible for the protective effect against stress related
brain damage and dysfunction of the extract. Therefore, N.nucifera extract is the potential
neuroprotective and memory enhancing agent. However, further researches are still required. |
| Keyword |
Nelumbo Nucifera, stress, memory impairment |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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