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Publication
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| Research Title |
Superoxide dismutase 2 gene (SOD2) polymorphisms and metabolic syndrome in Thai cigarette smokers |
| Date of Distribution |
22 January 2015 |
| Conference |
| Title of the Conference |
International Conference on “Research for Social Devotion” In Commemoration of the 50th Anniversary of Khon Kaen University, Thailand |
| Organiser |
Khon Kaen University |
| Conference Place |
Poj Sarasin Bullding, Khon Kaen University |
| Province/State |
Khon Kaen, Thailand |
| Conference Date |
22 January 2015 |
| To |
23 January 2015 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
- |
| Editors/edition/publisher |
- |
| Abstract |
Introduction: Cigarette smoking related oxidative stress contributes to the risk of metabolic syndrome (MetS). MetS is one of the major contributing factors for cardiovascular disease (CVD). Superoxide dismutase 2 (SOD2) is a mitochondrial antioxidant enzyme that catalyzes the dismutation of superoxide into hydrogen peroxide (H2O2). Genetic polymorphism of SOD2, rs4880 (T47C), has been reported that leads to the change of amino acid Val at position 16 to Ala and alters the secondary structure of mitochondrial targeting sequence of SOD2. The SOD2 with Ala16 is more efficiently imported into the mitochondrial matrix. Although the association between rs4880 and MetS component has been reported, it may also be modified by smoking.
Objective: The objective of this study was to investigate the association of SOD2 gene polymorphism (rs4880) with the risk of MetS in Thai cigarette smokers.
Method: A total of 212 Thai cigarette smokers with mean age 54.4±10.0 years including 54 former-smokers and 158 current-smokers were recruited. The prevalence of MetS was determined according to modified National Cholesterol Education Program III criteria. SOD2 gene polymorphism rs4880 was determined in genomic DNA using allele specific polymerase chain reaction (AS-PCR) technique.
Result: Among cigarette-smokers, the respective frequencies of T and C alleles for SOD2 were 73.1% and 26.9%. The SOD2 rs4880-C allele carriers were associated with an increased risk of MetS (OR = 1.99; 95%CI 1.08-3.70) and also had higher levels of waist/hip ratio, serum triglycerides (TG), and TG/HDL-C ratio than in TT subjects (p=0.027, 0.002, and 0.019, respectively).
Conclusion: The present study demonstrated the association of SOD2 gene polymorphism rs4880 with the risk of MetS in Thai cigarette smokers.
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย