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ข้อมูลการเผยแพร่ผลงาน
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| ชื่อบทความที่เผยแพร่ |
Antagonizing effects of Streblus asper leaf extract against chronic scopolamine-induced
memory deficits in mice. |
| วัน/เดือน/ปี ที่เผยแพร่ |
1 กุมภาพันธ์ 2559 |
| การประชุม |
| ชื่อการประชุม |
The 13th Asia Pacific Federation of Pharmacologist (APFP) Meeting |
| หน่วยงาน/องค์กรที่จัดประชุม |
The Pharmacological and Therapeutic Society of Thailand ร่วมกับ The Asia Pacific Federation of Pharmacologists |
| สถานที่จัดประชุม |
The Berkeley Hotel Pratunam |
| จังหวัด/รัฐ |
Bangkok, Thailand |
| ช่วงวันที่จัดประชุม |
1 กุมภาพันธ์ 2559 |
| ถึง |
3 กุมภาพันธ์ 2559 |
| Proceeding Paper |
| Volume (ปีที่) |
2016 |
| Issue (เล่มที่) |
- |
| หน้าที่พิมพ์ |
225 |
| Editors/edition/publisher |
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| บทคัดย่อ |
Scopolamine, a muscarinic receptor antagonist, has been widely used to induce memory deficits in experimental animals. Abolishing cerebral blood flow and inducing free radical injury are suggested to be the causes that trigger neuroinflammation induced by scopolamine. In addition, chronic administration of scopolamine led to marked histopathological alterations in the cerebral cortex, including neuronal degeneration and, in animals, is being used as a model of dementia to determine the effectiveness of potential new therapeutic agents for Alzheimer's disease. Streblus asper (SA) is one of Thai medicinal plant which has many polyphenolic compounds and has high antioxidant properties. Therefore, this study aimed to investigate effects of SA leaf extract on memory performance of mice treated with chronic scopolamine (SCO). Male ICR mice were divided into 6 experimental groups including control, SA200, SA400, SCO, SCO+SA200 and SCO+SA400 groups. In the control and SCO groups, mice were forced fed with distilled water, 5 ml/kg/day. Mice in SA200, SA400, SCO+SA200 and SCO+SA400 groups were forced fed with SA either at 200 or 400 mg/kg/day. Mice in SCO, SCO+SA200 and SCO+SA400 groups were also received SCO (2 mg/kg/day, i.p.) at 30 min after oral treatment. The treatments were done for 18 consecutive days. On days 15-16 and 17-18, mice were subjected to Morris water maze and passive avoidance tests, respectively. At the ends of the experiment, mice’s brain were collected and assayed for acetylcholinesterase (AChE) enzyme activity. The results showed that mice in SCO group had a significant increase in escape latency time in Morris water maze test and a significant decrease in latency time in passive avoidance test, when compared to the control. Interestingly, SA extract could reverse the memory deficits induced by chronic scopolamine treatment in both tests. Furthermore, the increasing of brain AChE activity found in SCO group was also antagonized by SA treatment. In conclusion, SA leaf extract could antagonize the memory impairment induced by chronic scopolamine treatment. The effects of SA extract might involve the anti-oxidant activity and/or increasing the acetylcholine level in the brain as seen by the decrease of AChE activity. These results suggest that SA leaf extract might be useful as an additional or alternative treatment in Alzheimer’s disease. |
| ผู้เขียน |
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| การประเมินบทความ (Peer Review) |
มีผู้ประเมินอิสระ |
| มีการเผยแพร่ในระดับ |
นานาชาติ |
| รูปแบบ Proceeding |
Abstract |
| รูปแบบการนำเสนอ |
Poster |
| เป็นส่วนหนึ่งของวิทยานิพนธ์ |
เป็น |
| ผลงานที่นำเสนอได้รับรางวัล |
ไม่ได้รับรางวัล |
| แนบไฟล์ |
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| Citation |
0
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