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Publication
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| Research Title |
Antagonizing effects of Streblus asper leaf extract against chronic scopolamine-induced
memory deficits in mice. |
| Date of Distribution |
1 February 2016 |
| Conference |
| Title of the Conference |
The 13th Asia Pacific Federation of Pharmacologist (APFP) Meeting |
| Organiser |
The Pharmacological and Therapeutic Society of Thailand ร่วมกับ The Asia Pacific Federation of Pharmacologists |
| Conference Place |
The Berkeley Hotel Pratunam |
| Province/State |
Bangkok, Thailand |
| Conference Date |
1 February 2016 |
| To |
3 February 2016 |
| Proceeding Paper |
| Volume |
2016 |
| Issue |
- |
| Page |
225 |
| Editors/edition/publisher |
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| Abstract |
Scopolamine, a muscarinic receptor antagonist, has been widely used to induce memory deficits in experimental animals. Abolishing cerebral blood flow and inducing free radical injury are suggested to be the causes that trigger neuroinflammation induced by scopolamine. In addition, chronic administration of scopolamine led to marked histopathological alterations in the cerebral cortex, including neuronal degeneration and, in animals, is being used as a model of dementia to determine the effectiveness of potential new therapeutic agents for Alzheimer's disease. Streblus asper (SA) is one of Thai medicinal plant which has many polyphenolic compounds and has high antioxidant properties. Therefore, this study aimed to investigate effects of SA leaf extract on memory performance of mice treated with chronic scopolamine (SCO). Male ICR mice were divided into 6 experimental groups including control, SA200, SA400, SCO, SCO+SA200 and SCO+SA400 groups. In the control and SCO groups, mice were forced fed with distilled water, 5 ml/kg/day. Mice in SA200, SA400, SCO+SA200 and SCO+SA400 groups were forced fed with SA either at 200 or 400 mg/kg/day. Mice in SCO, SCO+SA200 and SCO+SA400 groups were also received SCO (2 mg/kg/day, i.p.) at 30 min after oral treatment. The treatments were done for 18 consecutive days. On days 15-16 and 17-18, mice were subjected to Morris water maze and passive avoidance tests, respectively. At the ends of the experiment, mice’s brain were collected and assayed for acetylcholinesterase (AChE) enzyme activity. The results showed that mice in SCO group had a significant increase in escape latency time in Morris water maze test and a significant decrease in latency time in passive avoidance test, when compared to the control. Interestingly, SA extract could reverse the memory deficits induced by chronic scopolamine treatment in both tests. Furthermore, the increasing of brain AChE activity found in SCO group was also antagonized by SA treatment. In conclusion, SA leaf extract could antagonize the memory impairment induced by chronic scopolamine treatment. The effects of SA extract might involve the anti-oxidant activity and/or increasing the acetylcholine level in the brain as seen by the decrease of AChE activity. These results suggest that SA leaf extract might be useful as an additional or alternative treatment in Alzheimer’s disease. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย