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Publication
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| Title of Article |
Association of combined genetic variations in PPARγ, PGC-1α, and LXRα with coronary artery disease and severity in Thai population |
| Date of Acceptance |
3 March 2016 |
| Journal |
| Title of Journal |
Atherosclerosis |
| Standard |
ISI |
| Institute of Journal |
Elsevier |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2016 |
| Page |
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| Abstract |
Background: Atherosclerosis is a major cause of coronary artery
disease (CAD). Peroxisome proliferator-activated receptor-γ (PPARγ),
liver X receptor-α (LXRα), and PPARγ co-activator-1α (PGC-1α) are nuclear
factors that regulate lipid metabolism and inflammation implicated in
atherosclerosis. Although association of genetic variations in these
nuclear factors with CAD risk has been reported, it was based on
individual gene with inconsistent results among different ethnicities. We
investigated the association of combined gene-polymorphisms of these
nuclear factors with the risk and severity of CAD in Thai population.
Methods: Hospital-based subjects, 225 CADs and 162 non-CADs, were
genotyped for PPARγ C1431T, PGC-1α G482S, and LXRα -115G/A polymorphisms.
Gene-polymorphisms were examined for their association with CAD risk and
the severity of coronary atherosclerosis, assessed by both the number of
main vessels with ≥50% stenosis and Gensini score.
Results: The minor allele frequencies were 21.6% (1431T), 44.8% (482S),
and 10.7% (-115A). Initially, only 482S allele revealed association with
CAD risk [OR=1.64 (95%CI: 1.01-2.66), P=0.048] and severity [ORs for
four-vessel disease =1.23 (95%CI: 1.01-1.48), P=0.036, and for severe
atherosclerosis (score >32)=1.76 (95%CI: 1.05-2.96), P=0.032]. Combined
two risk-genotypes, 1431T/482S and -115GG/482S, also predicted the risk
of CAD [OR=1.87 (95%CI: 1.09-3.21), P=0.023 and OR=1.87 (95%CI: 1.15-3.03), P=0.012 respectively]. The combination of three risk-genotypes
further increased the risk of both CAD [OR=2.13 (95%CI: 1.12-4.06),
P=0.022] and severe coronary atherosclerosis [OR=2.09 (95%CI 1.09-4.02),
P=0.027].
Conclusion: The combined PPARγ C1431T, PGC-1α G482S, and LXRα -115G/A
polymorphisms increased the risk of CAD and predicted the severity of
coronary atherosclerosis in Thais. |
| Keyword |
PPARγ C1431T; PGC-1α G482S; LXRα -115G/A; atherosclerosis; severity of coronary atherosclerosis; coronary artery disease |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย