| Abstract |
The effect of ellagic acid on oxidative stress and hypertension induced
by Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) was investigated.
Male Sprague-Dawley rats were administrated with L-NAME (40 mg/kg/day) for five weeks.
L-NAME induced high systolic blood pressure (SBP) and increased heart rate (HR),
hindlimb vascular resistance (HVR) and oxidative stress. Concurrent treatment with ellagic
acid (7.5 or 15 mg/kg) prevented these alterations. Co-treatment with ellagic acid was
associated with up-regulation of endothelial nitric oxide synthase (eNOS) protein production
and alleviation of oxidative stress as indicated by decreased superoxide production in
the vascular tissue, reduced plasma malondialdehyde levels, reduced NADPH oxidase
subunit p47phox expression and increased plasma nitrate/nitrite levels. Our results indicate
that ellagic acid attenuates hypertension by reducing NADPH oxidase subunit p47phox
expression, which prevents oxidative stress and restores NO bioavailability. |
Publication
Journal Publication
ไทย