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Publication
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| Title of Article |
Protective effect of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 haplotype on coronary artery disease |
| Date of Acceptance |
11 July 2016 |
| Journal |
| Title of Journal |
Blood Coagulation & Fibrinolysis |
| Standard |
SCOPUS |
| Institute of Journal |
Wolters Kluwer Health | Lippincott Williams & Wilkins |
| ISBN/ISSN |
0957-5235 |
| Volume |
28 |
| Issue |
4 |
| Month |
June |
| Year of Publication |
2017 |
| Page |
286-294 |
| Abstract |
Genetic variations of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) and von Willebrand factor (vWF) were related to ADAMTS13 levels. Reduction of ADAMTS13 activity may affect atherosclerotic progression. However, the associations of polymorphisms of these genes with
coronary artery disease (CAD) are still unclear. This study, therefore, aimed to investigate the relationship of genetic variations and haplotypes of ADAMTS13 and vWF with CAD risk in Thais. A case–control study was performed in 197 CAD and 135 non-CAD patients. Genetic polymorphisms of
ADAMTS13 (P475S, Q448E, rs2073932, P618A, A900V, S903L, rs652600, and rs4962153) and vWF (V1565L and Y1584C) along with ADAMTS13 activity, vWF antigen and vWF activity were examined in the patients. The vWF V1565L polymorphism was associated with increased ADAMTS13 activity, whereas none of ADAMTS13 polymorphisms or haplotypes was associated with its activity. Interestingly, haplotype analysis indicated that the QAGA or H4 haplotype of ADAMTS13 gene had a protective effect on CAD after adjustment for ABO blood group [odds ratio (OR) = 0.3, 95% confidence interval (CI) = 0.1, 0.6] and major CAD risk
factors (OR = 0.3, 95% CL = 0.1, 0.7). However, the combination of H4 haplotype and the L allele of V1565L was not associated with increased ADAMTS13 activity when compared with the V allele. ADAMTS13 haplotype had an independent protective effect on CAD and genetic variation
of vWF V1565L polymorphism modulates ADAMTS13 activity. |
| Keyword |
atherosclerosis, coronary artery disease, genetic variation, von Willebrand factor |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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