| Research Title |
Moringa oleifera leaf extract decreases arterial blood pressure and vascular reactivity to adrenergic stimulation in L-NAME hypertensive rats |
| Date of Distribution |
27 October 2016 |
| Conference |
| Title of the Conference |
7th Scientific Meeting of Asian Society for Vascular Biology |
| Organiser |
The Buddhist Tzu Chi General Hospital in Hualien and Asian Society for Vascular Biology |
| Conference Place |
Xie-Li Auditorium, Xie-Li Building, Buddhist Tzu Chi Medical Center |
| Province/State |
Hualien, Taiwan |
| Conference Date |
27 October 2016 |
| To |
29 October 2016 |
| Proceeding Paper |
| Volume |
7 |
| Issue |
1 |
| Page |
110 |
| Editors/edition/publisher |
|
| Abstract |
Sympathetic overactivity resulting in increased total peripheral resistance plays a major role in pathogenesis of hypertension. Moringa oleifera is a tropical plant distributed in Thailand. The leaf
of M. oleifera is used in Thai food as well as folk medicine for treatment of many diseases
including cardiovascular problems. This study aimed to investigate the preventive effect of aqueous
leaf extract of M. oleifera (MOE) on hemodynamic status and adrenergic reactivity in Nω-nitro-L-arginine-methylester (L-NAME) induced hypertensive rats. Male Wistar rats were
administered daily with L-NAME (50 mg/kg/day) in drinking water for three weeks. On the last day,
hemodynamic measurements on anesthetized rats were done via femoral artery catheterization. They developed significant increases in systolic and diastolic blood pressure (SBP and DBP), and heart rate (HR). Isolated mesenteric vascular reactivity to adrenergic stimulation, a selective
α1-adrenoceptor agonist; phenylephrine (Phe; 0.01-1 mmol) and perivascular nerve stimulation
(PNS; 2-16 Hz) were significantly increased. Concurrent orally treatment with MOE at doses of 30 and 60 mg/kg/day caused the decreases in SBP, DBP and HR. MOE administration resulted in
dose-dependent reduction of hyper-reactivity of vascular response to Phe. Moreover,
MOE-treatment at both doses significantly reduced the hyper-reactivity to PNS to the normal levels.
It can be concluded that MOE has an antihypertensive activity in L-NAME induced hypertensive rats. The antihypertensive effect may be due to its suppressing activity on adrenergic hyperactivity
of resistance vascular bed. This result suggests that MOE may be useful as a dietary supplement
against hypertension and could probably alleviate sympathetic symptoms. |
| Author |
|
| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
|
|
|
Publication
Journal Publication
ไทย