2012 ©
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Journal Publication
Title of Article The Three Most Common Human Papillomavirus Oncogenic Types and Their Integration State in Thai Women with Cervical Precancerous Lesions and Carcinomas  
Date of Acceptance 5 August 2014 
Journal
     Title of Journal Journal of Medical Virology  
     Standard ISI 
     Institute of Journal Wiley Online Library 
     ISBN/ISSN  
     Volume 2014 
     Issue 86 
     Month พฤศจิกายน
     Year of Publication 2017 
     Page 1911-1919 
     Abstract To understand the potential role in cervical cancer development of the three most common high-risk human papillomavirus (HRHPVs) in Thai women, HPV genotypes and viral genome statuses in different cervical lesions were investigated. Cervical tissues consisting of no cervical intraepithelial neoplasia (84 cases), grade I cervical intraepithelial neoplasia (176 cases), grade II–III cervical intraepithelial neoplasia (91 cases), and squamous cell carcinoma (66 cases) were subjected for HPV genotyping by polymerase chain reaction (PCR) and reverse line blot hybridization assay and for HPV genome status determination by amplification of papillomavirus oncogene transcripts (APOT) assay. HPV prevalence was 28.6% in no cervical intraepithelial neoplasia, 40.3% in grade I cervical intraepithelial neoplasia, 70.3% in grade II–III cervical intraepithelial neoplasia and 86.4% in squamous cell carcinoma cases. The three most common HR-HPV types were HPV 16, 58, and 18 which were distributed in all cervical lesions. HPV physical statuses could be investigated in 4 no cervical intraepithelial neoplasias, 2 grade I cervical intraepithelial neoplasias, 28 grade II–III cervical intraepithelial neoplasias and 31 squamous cell carcinomas. The integrated-derived transcripts were found 3.6% in grade II–III cervical intraepithelial neoplasia and 48.4% in squamous cell carcinoma, whereas no viral genome integration was found in the group of no cervical intraepithelial neoplasia or grade I cervical intraepithelial neoplasia samples. The frequencies of HR-HPV integration in squamous cell carcinoma were found 40%, 100%, 20% of HPV 16, 18, and 58. This study indicates the oncogenic potential ability of the three most common HR-HPVs associated with cervical cancer progression.  
     Keyword human papillomavirus; physical status; genotype distribution; cervical cancer 
Author
537070011-0 Miss SIRINART AROMSEREE [Main Author]
Medicine Doctoral Degree

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