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Publication
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| Title of Article |
Two new bioactive iridoids from Rothmannia wittii |
| Date of Acceptance |
14 July 2016 |
| Journal |
| Title of Journal |
Fitoterapia |
| Standard |
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| Institute of Journal |
Elsevier |
| ISBN/ISSN |
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| Volume |
2016 |
| Issue |
113 |
| Month |
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| Year of Publication |
2016 |
| Page |
97-101 |
| Abstract |
The first reported study of the isolation and identification of compounds from the bark and fruit of Rothmannia
wittii yielded two new iridoids, 6β-hydroxy-10-O-acetylgenipin (1) and 10-O-acetylmacrophyllide (2) together
with six known iridoids; 6β-hydroxygenipin (3), genipin (4), garjasmine (5), cerbinal (6), and mixture of β-
gardiol (7) and α-gardiol (8); benzoic acid (9); vanillic acid (10); and stigmasterol (11). Their structures were
elucidated by spectroscopic methods. Iridoid 1 showed antimycobacterial activity against Mycobacterium tuberculosis
with a MIC value of 12.50 μg/mL. Iridoid 2 showed cytotoxicity against the NCI-H187 cancer cell line with
an IC50 value of 6.82 μg/mL. In addition, 2 and 5 exhibitedweak cytotoxic activity against KB andMCF-7 cell lines,
while 4 was active against the NCI-H187 cancer cell line. |
| Keyword |
Rothmannia wittii, Iridoid, Macrophyllide, Genipin, Garjasmine, Cerbinal |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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