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Publication
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| Research Title |
Association of Atorvastatin and Lipid Parameters with Clopidogrel Responsiveness in Thai Patients with Acute Coronary Syndrome
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| Date of Distribution |
7 December 2016 |
| Conference |
| Title of the Conference |
The 3rd Pan-Asian Biomedical Science Conference 2016 |
| Organiser |
Biomedical Science Programme,School of Diagnostic & Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, |
| Conference Place |
The Premiera Hotel Kuala Lumpur, Malaysia |
| Province/State |
Kuala Lumper |
| Conference Date |
7 December 2016 |
| To |
8 December 2016 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
56-57 |
| Editors/edition/publisher |
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| Abstract |
Atorvastatin co-administered with clopidogrel is generally used in patients with acute coronary syndrome (ACS). Due to their common metabolite, clopidogrel low responsiveness and high platelet reactivity may occur. However, there has been much controversy regarding possible drug interactions via this pathway. Furthermore, high platelet aggregation in hyperlipidemia patients has been widely described. The present study therefore aimed to investigate the effect of atorvastatin and lipid parameters on clopidogrel responsiveness in Thai ACS subjects. The closure times (CT) was determined in 36 ACS subjects undergoing percutaneous coronary intervention by using platelet function analyzer-200. The CT ≤ 106 and exceeding 106 seconds were classified as clopidogrel low-responder and clopidogrel responder, respectively. Lipid parameters including serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholestesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) were measured in all subjects. The results demonstrated that the CT was significantly lower in atorvastatin concomitant than those in non-concomitant use with clopidogrel (p=0.019). Interestingly, atorvastatin co-administered with clopidogrel revealed an increased risk for clopidogrel low responsiveness compared to clopidogrel without atorvastatin [OR (95%CI) = 6.1 (1.3, 31.1)]. The levels of TC, LDL-C, and LDL-C/HDL-C ratio in clopidogrel low-responder were significantly higher than those in responder group (p=0.039, 0.021, and 0.049, respectively). Moreover, high levels of TC and LDL-C were associated with an increased risk of clopidogrel low responsiveness [OR (95% CI) = 1.02 (1.00, 1.04) and 1.03 (1.00, 1.06), respectively]. In conclusion, these findings confirmed that lipid parameters and coadmistration of atorvastatin with clopidogrel were associated with clopidogrel responsiveness in Thai ACS subjects.
Key words: ACS; atorvastatin; clopidogrel; lipid parameters; PFA-200
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| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย