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Publication
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| Research Title |
Association of ADAMTS13 Polymorphisms with Risk of Diabetes Mellitus |
| Date of Distribution |
7 December 2016 |
| Conference |
| Title of the Conference |
3rd Pan-Asian Biomedical Science Conference 2016: Biomedical Science: Frontier in Global Health Challenges |
| Organiser |
Biomedical Science from University of Malaya (UM), Universiti Kebangsaan Malaysia (UKM), Universiti Sains Malaysia (USM), Universiti Putra Malaysia (UPM) and International Islamic University of Malaysia (IIUM) |
| Conference Place |
Premiera Hotel Kuala Lumpur |
| Province/State |
Kuala Lumpur, Malaysia |
| Conference Date |
7 December 2016 |
| To |
8 December 2016 |
| Proceeding Paper |
| Volume |
- |
| Issue |
- |
| Page |
- |
| Editors/edition/publisher |
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| Abstract |
Association of ADAMTS13 Polymorphisms with Risk of Diabetes Mellitus
Lasom Supakanya 1, 2, Komanasin Nantarat 2, 3, Settasatian Nongnuch 2, 4, Settasatian Chatri 2, 5, Kukongviriyapan Upa 2, 6, Intharapetch Pongsak 2, 7, Senthong Vichai 2, 8
1 Ph.D. Candidate in Biomedical Sciences Program, Graduate School, Khon Kaen University, Khon Kaen 40002, Thailand
2 Cardiovascular Research Group, Khon Kaen University, Khon Kaen 40002, Thailand
3 Department of Clinical Microscopy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
4 Department of Clinical Chemistry, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand
5 Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
6 Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
7 Queen Sirikit Heart Center of the Northeast, Khon Kaen University, Khon Kaen 40002, Thailand
8 Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
* Presenter email: jae_numnun@hotmail.com
Abstract
Diabetes mellitus (DM), a major risk factor for coronary artery disease (CAD), is associated with an alteration in haemostatic system. High concentration of von Willebrand factor (vWF) which regulates platelet adhesion and aggregation was associated with DM. Upon released, vWF was cleaved by a disinte-grin and metalloprotease with a thrombospondin type 1 motif, member 13 (ADAMTS13). Therefore, this study aimed to evaluate the associations of ADAMTS13 polymorphisms, vWF antigen, vWF and ADAMTS13 activities, and vWF/ADAMTS13 ratio with risk of DM and CAD in Thai. A case-control study was performed in 190 DM and 87 non-DM subjects. vWF and ADAMTS13 activities as well as vWF antigen were evaluated by collagen binding assay and ELISA technique, respectively. ADAMTS13 polymorphisms were determined by restriction fragment length polymorphism. There were no significant differences of vWF antigen, vWF and ADAMTS13 activities, and vWF/ADAMTS13 ratio between DM and non-DM subjects. The alleles 448E, rs2073932G, rs652600A and EGA haplotype were associated with increased DM risk after adjustment for age, sex, hypertension and metabolic syndrome [OR (95% CI) = 2.3 (1.2, 4.4), 2.3 (1.2, 4.4), 2.3 (1.2, 4.6) and 1.7 (1.1, 2.8), respectively]. The EGA haplotype had higher HOMA-IR (p = 0.014) and fasting blood glucose (FBG) levels (p-trend = 0.013) when compared to reference haplotype. However, none of polymorphisms or haplotypes was associated with ADAMTS13 activity and CAD risk. In conclusion, the results suggested that the ADAMTS13 haplotype (EGA) was associated with HOMA-IR and FBG concentration which may lead to an increased risk of DM in Thai.
Consistent
with the results derived from the single-locus analysis, haplotype
analysis revealed that the haplotype carrying the Thr147 allele
was associated with increased risk of CHD in France
Keywords: ADAMTS13; von Willebrand factor; polymorphism; diabetes mellitus
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย