| Research Title |
Antifertility effects of Leucaena leucocephala aqueous shoot tips plus young leaves extract in adult male rats |
| Date of Distribution |
26 January 2017 |
| Conference |
| Title of the Conference |
The 2nd International Conference on Herbal and Traditional Medicine (HTM2017) |
| Organiser |
Faculty of Pharmaceutical Sciences, Khon Kaen University |
| Conference Place |
Asia Hotel |
| Province/State |
Bangkok |
| Conference Date |
25 January 2017 |
| To |
27 January 2017 |
| Proceeding Paper |
| Volume |
2 |
| Issue |
1 |
| Page |
198 |
| Editors/edition/publisher |
|
| Abstract |
Introduction: Recently, the antifertility studies of plant or herb are conducting to search for male contraceptive plants that can reduce the side effects from synthetic contraceptives. Although Leucaena leucocephala (LL) can cause hair loss and infertility in cattle, the antifertility effects of LL have never been systemically reported. Therefore, this study aimed to investigate effects of LL aqueous shoot tips plus young leaves extract on reproductive system in male rats. Methods: Shoot tips plus young leaves of LL were harvested in Khon Kaen province. Ten male rats were divided into two groups; control group was orally received with distilled water and LL group was received with 1500 mg/kg BW of LL extract for consecutive 60 days. Results and Discussion: The results showed that LL-treated rats had significant increases of malondialdehyde level, percentage of sperm acrosome reaction, and abnormal sperm head as compared with the control. Additionally, LL extract significantly reduced the sperm count, follicle-stimulating and testosterone hormone levels, and expression of testicular steroidogenic acute regulatory (StAR) protein. Moreover, seminiferous tubular atrophy and few germ cells in some tubules were observed in LL-treated rats. However, the extract had no adverse effect on body and reproductive organ weights, luteinizing hormone level, and expression of tyrosine phosphorylated proteins. Conclusion: These findings suggested that aqueous shoot tips plus young leaves extract of LL has male antifertility property in rats. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
Bronze Medal Award (oral presentation) |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
Faculty of Pharmaceutical Sciences, Khon Kaen University |
| Date of awarding |
27 มกราคม 2560 |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย