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Publication
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| Research Title |
Phyllanthus emblica L. leaves extract ameliorates testicular damages in chronic stress rats
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| Date of Distribution |
26 January 2017 |
| Conference |
| Title of the Conference |
The 2nd International Conference on Herbal and Traditional Medicine (HTM2017) |
| Organiser |
Faculty of Pharmaceutical Sciences, Khon Kaen University |
| Conference Place |
Asia Hotel |
| Province/State |
Bankok |
| Conference Date |
25 January 2017 |
| To |
27 January 2017 |
| Proceeding Paper |
| Volume |
2 |
| Issue |
1 |
| Page |
199 |
| Editors/edition/publisher |
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| Abstract |
Introduction: Stress adversely affects male reproductive organs, causing infertility. Although various parts of Phyllanthus emblica L. (PE) extract have been shown to have high antioxidant capacity, protective effects of PE leaves extract on male reproductive parameters in chronic stress have never been elucidated. This study aimed to investigate effects of PE aqueous leaves extract on testicular protein markers in chronic stress rats. Methods: Male rats were divided into 4 groups (control, chronic stress [CS], PE 50, and 100 mg/kgBW+CS). In treatment group, animals were fed with different doses of PE extract before chronic stress induction by immobilization (4h/day) and forced-cold swimming (15 min/day) for 40 consecutive days. The sperm quality, testicular histology, and levels of corticosterone, testosterone, and malondialdehyde (MDA) were examined. The expressions of testicular steroidgenic acute regulatory (StAR) and tyrosine phosphorylated proteins were analyzed by immuno Western blot. Results: PE significantly increased sperm concentration and decreased corticosterone and MDA levels, sperm head abnormality (%), and acrosome reacted sperm (%) in CS rats. PE could also minimize testicular histopathology in CS rats. Moreover, PE altered the intensity of tyrosine phosphorylated proteins (14, 51, and 60 kDas), except of StAR protein in CS testis. Conclusion: PE leaves extract can prevent testicular damages in chronic stress rats. |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
false |
| Presentation awarding |
true |
| Award Title |
Golden Medal Award (รางวัลที่ 1) |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
aFculty of Pharmaceutical Sciences, Khon Kaen University |
| Date of awarding |
27 มกราคม 2560 |
| Attach file |
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| Citation |
0
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Journal Publication
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