| Title of Article |
RELATIONSHIP BETWEEN GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND UGT1A1 GENOTYPES IN NEONATES WITH HYPERBILIRUBINEMIA |
| Date of Acceptance |
10 April 2017 |
| Journal |
| Title of Journal |
Southeast Asian Journal of Tropical Medicine and Public Health |
| Standard |
SCOPUS |
| Institute of Journal |
The SEAMEO Regional Tropical Medicine and Publ ic Health Network (SEAMEO TROPMED Network) |
| ISBN/ISSN |
|
| Volume |
48 |
| Issue |
3 |
| Month |
May |
| Year of Publication |
2017 |
| Page |
|
| Abstract |
Hyperbilirubinemia is one of the most common problems in neonates. Homozygosity of substitution/indel in coding and promoter regions of UGT1A1 (encoding uridine diphosphate glucuronosyl transferase 1A1) have been reported to pose additional risk factors for hyperbilirubinemia in glucose-6-phophate dehydrogenase (G6PD-deficient neonates. The relationship between these mutations on neonatal hyperbilirubinemia has not been investigated in the northeast Thailand. UGT1A1 TA(7) promoter mutation and 211G>A variant were analyzed in 108 G6PD-normal and 111 -deficient neonates with hyperbilirubinemia. There are significant differences in peak total serum bilirubin level among G6PD-normal and -deficient neonates carrying wild type UGT1A1 (n = 67 and 53 respectively), 211A/A (n = 1 and 1), TA(7)/TA(7) (n = 1 and 1), 211G/A (n = 12 and 17), and TA(6)/TA(7) (n = 20 and 12). Percent hospital re-admission with hyperbilirubinemia is significantly lower in neonates carrying UGT1A1 TA(6)/TA(7). Further studies with a larger study population are needed to verify these findings. |
| Keyword |
G6PD deficiency, UGT1A1, neonatal hyperbilirubinemia, northeastern Thailand |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
|
| Citation |
0
|
|
|
Publication
Journal Publication
ไทย