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Journal Publication
Title of Article Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47phox and iNOS in nitric oxide deficient rats 
Date of Acceptance 31 March 2017 
     Title of Journal Annals of Anatomy 
     Standard SCOPUS 
     Institute of Journal Elsevier 
     ISBN/ISSN http://dx.doi.org/10.1016/j.aanat.2017.03.007 
     Volume 2017 
     Issue 212 
     Month March
     Year of Publication 2017 
     Page 27-36 
     Abstract Nω-Nitro-l-arginine methyl ester (l-NAME)-induced hypertension and cardiovascular remodeling are associated with oxidative stress and inflammation. Garcinia mangostana Linn., has been reported to have antioxidant and anti-inflammatory properties. This study investigated whether G. mangostana pericarp extract (GME) could prevent l-NAME-induced hemodynamic alterations, cardiovascular remodeling, oxidative stress and inflammation in rats. Male Sprague-Dawley rats were given 40 mg/kg/day of L-NAME in drinking water to induce hypertension, and were simultaneously treated with GME at a dose of 200 mg/kg/day. Rats that received l-NAME for five weeks had high blood pressure, left ventricular hypertrophy and thickening of aortic wall. Vascular superoxide production, plasma malondialdehyde (MDA), and plasma tumor necrosis factor alpha (TNF-) were significantly increased in l-NAME-hypertensive rats (p < 0.05). This was consistent with up-regulation of the p47phox NADPH oxidase subunit and iNOS protein expression in aortic tissues (p < 0.05). Low levels of plasma nitric oxide metabolites were observed in L-NAME hypertension. GME prevented the development of hypertension and cardiovascular remodeling induced by L-NAME with reduced oxidative stress and inflammation. These data suggest that GME had a protective effect against L-NAME-induced hypertension and cardiovascular remodeling via suppressing p47phox NADPH oxidase subunit and iNOS protein expression resulting in enhancing NO bioavailability. 
     Keyword Garcinia mangostana pericarp extract; Hypertension; NO Bioavailability; Oxidative stress; Inflammation; Cardiovascular morphology 
577070001-7 Mr. PATTANAPONG BOONPROM [Main Author]
Medicine Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
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