| Abstract |
Background: High levels of von Willebrand factor (vWF) and low levels of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) were associated with risk of coronary artery disease (CAD) and development of atherosclerosis. Moreover, elevated vWF was also associated with diabetes mellitus (DM).
Aims: This study aimed to assess the association of ADAMTS13 activity and vWF levels with severity of coronary stenosis in DM patients.
Methods: Type 2 DM with CAD patients (n = 62) and non-DM without CAD subjects (control group, n = 84) were recruited. Severity of coronary stenosis was considered by using Gensini score and the DM with CAD subjects were divided into 2 groups; high (Gensini score ≥ 20, n = 46) and low-medium score (Gensini score < 20, n = 16). vWF antigen and activity were measured by in-house ELISA and collagen binding assay (CBA), while ADAMTS13 activity was determined by residual-CBA.
Results: vWF antigen/ADAMTS13 activity (vWF/ADAMTS13) ratio was likely to increase in DM with CAD patients compared to control group (p for trend = 0.046). However, no significant differences of other parameters were observed between both groups. DM patients with high Gensini score showed elevated ADAMTS13 activity and tendency of decreased vWF/ADAMTS13 ratio compared to those with low-medium score [(73.4±17.2% vs 59.5±22.5%, p = 0.037) and (1.1±0.6 vs 1.5±1.3, p for trend = 0.024), respectively]. Furthermore, multivariate regression analysis showed that after adjustment for hypertension and HDL-C, DM with high vWF/ADAMTS13 ratio were significantly associated with low-medium Gensini score [OR (95% CI) = 5.4 (1.1, 26.9)].
Conclusion: This study suggested that high vWF/ADAMTS13 ratio was associated with low-medium Gensini score, which may indicate the association of ADAMTS13 and vWF levels with early atherosclerosis in DM patients. However, further study with larger sample size is needed to confirm the association.
Keywords: ADAMTS13, vWF, coronary stenosis, Gensini score, diabetes mellitus.
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Publication
Journal Publication
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