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Publication
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| Title of Article |
Cardiovascular Performance Following Continuous Positive Airway Pressure in Patients with Severe Obstructive Sleep Apnea |
| Date of Acceptance |
3 October 2017 |
| Journal |
| Title of Journal |
Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology |
| Standard |
SCOPUS |
| Institute of Journal |
ejmanager |
| ISBN/ISSN |
http://dx.doi.org/10.5350/Sleep.Hypn.2017.19.0150 |
| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2017 |
| Page |
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| Abstract |
ABSTRACT
Background: Obstructive sleep apnea (OSA) may lead to decreased exercise capacity. We investigated whether continuous
positive airway pressure (CPAP) treatment improved cardiovascular performance in OSA patients.
Methods: Forty healthy subjects (control group) and 40 severe OSA patients were recruited. The two groups were matched for
age, gender, and body mass index. OSA patients were assigned to CPAP and non-CPAP treatment groups in equal numbers.
All subjects underwent cardiopulmonary exercise testing (CPET) using a treadmill and an incremental protocol until symptom
limitation (Day 0). CPET was repeated at Day 180 in the CPAP treatment group.
Results: OSA patients had lower maximal oxygen consumption (V’O2max) (1666.3 ± 451.3 vs. 1375.6 ± 227.7 ml/min, 28.2 ±
5.5 vs. 18.9 ± 3.8 ml/min/kg) (p < 0.001), higher maximal V’E/V’CO2
(p < 0.01), V’E/V’O2
(p < 0.001), heart rate (HR) reserve (p
< 0.001), and blunted HR recovery (HRR) at 1-5 min (p < 0.001) compared to controls. V’O2max was negatively correlated with
AHI (R2
= 0.1363, p < 0.05). In the CPAP but not in non-CPAP treatment group, both V’O2max (p < 0.05), HRR (p < 0.001), and HR
reserve (p < 0.05) were improved on Day 180 compared to Day 0.
Conclusion: Our study demonstrates that CPAP therapy for six months provides clinical benefits by improving cardiovascular
performance. |
| Keyword |
Obstructive sleep apnea, continuous positive airway pressure, cardiopulmonary exercise testing, heart rate recovery |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
1
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Journal Publication
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