|
|
Publication
|
| Title of Article |
Oxidative Stress and Inflammation after Continuous Positive Airway Pressure Therapy in Patients with Severe Obstructive Sleep Apnea. |
| Date of Acceptance |
29 December 2017 |
| Journal |
| Title of Journal |
Sleep and Hypnosis: A Journal of Clinical Neuroscience and Psychopathology |
| Standard |
SCOPUS |
| Institute of Journal |
ejmanager |
| ISBN/ISSN |
1302-1192 |
| Volume |
2018 |
| Issue |
4 |
| Month |
December |
| Year of Publication |
2018 |
| Page |
275-282 |
| Abstract |
Background: It has been demonstrated that moderate to severe obstructive sleep apnea (OSA) leads to generation of reactive
oxygen species and inflammation. We evaluated whether continuous positive airway pressure (CPAP) treatment progressively
improves oxidative stress and inflammation, and whether an association exists in severe OSA patients between severity of OSA
and biomarkers of oxidative stress and inflammation.
Methods:Forty patients with severe OSA (apnea hypopnea index, AHI: 37.8 ± 5.8 /h) that were newly diagnosed using
polysomnography were recruited. Patients received CPAP treatment for six months. Patients were assigned to CPAP and nonCPAP
treatment groups in equal numbers. The levels of malondialdehyde (MDA), alanine aminotransferase (ALT), aspartate
aminotransferase (AST), high sensitivity C-reactive protein (hs-CRP), neutrophils to lymphocyte ratio (NLR), and platelet to
lymphocyte ratio (PLR) were measured prior to and after three and six months of therapy.
Results: AHI was positively correlated with MDA (r = 0.4728, p < 0.01), ALT (r = 0.6081, p < 0.001), AST (r = 0.6299, p < 0.001),
NLR (r = 0.3943, p < 0.05), PLR (r = 0.3319, p < 0.05), and hs-CRP (r = 0.5728, p < 0.001). In the CPAP but not in non-CPAP
treatment group, MDA, AST, NLR, PLR, and hs-CRP levels (p < 0.001), and ALT (p < 0.05) levels were improved after three and
six months of treatment. After six months, MDA levels decreased further compared to MDA levels at three months, and this
decrease was significant (p < 0.001).
Conclusion: Our study demonstrates that CPAP therapy in severe OSA patients produces clinical benefits by improving
oxidative stress and inflammation progressively, and that severity of OSA is correlated with oxidative stress and inflammation. |
| Keyword |
obstructive sleep apnea, continuous positive airway pressure, oxidative stress, liver inflammation, systemic inflammation |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
|
| Citation |
1
|
|
|
|
|
|
|
|
|
Journal Publication
ไทย