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Publication
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| Title of Article |
Associations between airway inflammation and indices of sleep apnea severity in obstructive sleep apnea patients. |
| Date of Acceptance |
12 January 2018 |
| Journal |
| Title of Journal |
ศรีนคริทร์เวชสาร |
| Standard |
TCI |
| Institute of Journal |
ฝ่ายวิชาการ คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น อ.เมือง จ.ขอนแก่น |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2018 |
| Page |
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| Abstract |
Background and Objectives: Obstructive sleep apnea (OSA) is a complex disorder that consists of
recurrent upper airway collapse, intermittent hypoxia (IH), and sleep fragmentation. Previous studies
suggest that may play a role in airway inflammation. Fractional exhaled nitric oxide (FeNO) levels have
been used as markers for airway inflammation. This study investigated the association of sleep apnea
severity with airway inflammation in patients with OSA.
Methods: Forty OSA patients diagnosed with medical specialists by the polysomnography (PSG) and
submitted to sleep studies were evaluated. FeNO levels were measured following PSG.
Results: The average apnea hypopnea index (AHI) of patients was 37.8 ± 5.8 /hour, arousal index 56.7 ±
14.5 /hour, apnea index 19.0 ± 9.4/hour and nadir oxygen saturation was 87 ± 4 %. The average level of
FeNO was 27.7±2.2 ppb. FeNO levels were positively correlated with AHI (R 2 = 0.3585, p < 0.001),
arousal index (R 2 = 0.2598, p < 0.001), and apnea index (R 2 = 0.1719, p < 0.01).
Conclusion: This study demonstrates that airway inflammation was associated with OSA severity indices.
Further study should be conducted in mild to severe OSA patients in order to definitely establish the
association between airway inflammation and sleep apnea indices. |
| Keyword |
Obstructive sleep apnea, Airway inflammation |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
ชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
1
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Journal Publication
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