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Publication
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| Title of Article |
Association of ADAMTS13 polymorphisms with severity of coronary stenosis in type 2 diabetes mellitus |
| Date of Acceptance |
18 March 2018 |
| Journal |
| Title of Journal |
Journal of Research in Medical Sciences |
| Standard |
SCOPUS |
| Institute of Journal |
Isfahan University of Medical Sciences(IUMS) |
| ISBN/ISSN |
1735-1995 |
| Volume |
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| Year of Publication |
2018 |
| Page |
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| Abstract |
Background: The imbalance of von Willebrand factor (vWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif member 13 (ADAMTS13) has been associated with atherosclerosis progression. A high level of vWF which regulates thrombus formation was associated with diabetes mellitus (DM) and some ADAMTS13 and vWF polymorphisms have effects on their levels. Therefore, this study aimed to evaluate the associations of ADAMTS13 and vWF polymorphisms and their levels with DM and severity of coronary stenosis. Materials and Methods: Eighty seven DM and 84 control subjects were recruited. vWF and ADAMTS13 activities as well as vWF antigen were measured by collagen binding assay (CBA), residual-CBA and in-house ELISA, respectively. ADAMTS13 and vWF polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism. Results: The E and G alleles, and AA genotype of ADAMTS13 Q448E, rs2073932 and rs652600, respectively, were independently associated with DM [OR (95% CI)=2.5 (1.1, 5.6), 2.3 (1.0, 5.2) and 4.7 (1.2, 18.6), respectively]. Moreover, E allele and AA genotype of Q448E and rs652600 were also significantly associated with multi-vessel disease [OR (95% CI)=2.2 (1.0, 4.8) and 3.2 (1.0, 10.0), respectively] while the E and G allele of Q448E and rs2073932 were associated with high Gensini score [OR (95% CI)=2.3 (1.1, 4.9) and 2.3 (1.1, 5.1), respectively]. Conclusion: Association of ADAMTS13 polymorphisms with DM, number of vessel stenosis and Gensini scoremay indicate the possible contribution of ADAMTS13 polymorphisms to atherosclerosis progression and severity of coronary stenosis in DM.
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| Keyword |
ADAMTS13, coronary stenosis, diabetes mellitus, polymorphism |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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