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Publication
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| Research Title |
The Correlations Between Insulin Resistance and Serum Lipid Profile in Thai Dyslipidemic Participants. |
| Date of Distribution |
6 December 2017 |
| Conference |
| Title of the Conference |
45th PHYSIOLOGICAL SOCIETY OF THAILAND ANNUAL MEETING: "Translational Physiology: Implications in Health and Disease" |
| Organiser |
PHYSIOLOGICAL SOCIETY OF THAILAND |
| Conference Place |
The AVANI Khon Kaen Hotel and Convention Centre Khon Kaen, Thailand. |
| Province/State |
Khon Kaen, Thailand. |
| Conference Date |
6 December 2017 |
| To |
8 December 2017 |
| Proceeding Paper |
| Volume |
6-8 December,2017 |
| Issue |
6-8 December,2017 |
| Page |
62 |
| Editors/edition/publisher |
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| Abstract |
Abstract
Insulin resistance is a pathological condition in which cells fail to respond normally to the
hormone insulin. The correlation of insulin resistance and blood lipid profile are controversial.
This study was set to test the relationship between insulin resistances and serum lipid profile in
Thai dyslipidemic participants. Fifteen dyslipidemic participants (13 women and 2 men, aged
49±4.35 yr, body mass index 27.2±3.55, waist-to-hip ratio 0.88±0.04, percent of body fat
39.01±8.05 % and mean arterial pressure 93.42±7.96 mmHg.) were studied. Blood samples were
collected after overnight fasting 8 hours to measure lipid profile, glucose, and insulin level.
Serum lipid profiles were analyzed using a Reflotron (ReflotronPlus, Boehringer Mannheim,
Germany). Blood glucose concentration was measured using a glucose analyzers (YSI 2300
STAT PLUSTM). The concentration of serum insulin was analyzed using a radio immunoassay
kit. Insulin resistance index was calculated using Homeostatic Model Assessment of Insulin
Resistance, HOMA-IR (Fasting insulin (mIU/L)xfasting glucose(mg/dL)] /405). These
participants had abnormal lipid profile and lipid ratio (total cholesterol (TC) 200.529.6
mg /dL,triglycerides (TG) 175.978.00 mg /dL, low density lipoprotein cholesterol (LDL-c)
126.428.2 mg /dL, high density lipoprotein cholesterol (HDL-c) 50.4116.23 mg /dL. ,TC /HDLc
ratio 4.271.10 and TG /HDL-c ratio 4.122.59). They also had high fasting serum insulin level
(15.310.6 uIU/ml), and HOMA-IR score (3.593.01), but normal fasting blood glucose
(90.619.5 mg /dL).They had positive correlation between HOMA-IR and serum insulin and (r
=0.95,p<0.01) and fasting blood glucose (r=0.6, p<0.05). However, we do not find the
correlation between lipid profile and insulin resistancein these patients. The results of this study
suggest that lipid profile and insulin resistance are independently affected in dyslipidemic
patients. However, fasting blood glucose concentration shows normal. This could be due to
moderate insulin resistance and middle age. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
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| Citation |
0
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Journal Publication
ไทย