2012 ©
             Publication
Journal Publication
Title of Article Antitumor Ability of KT2 Peptide Derived from Leukocyte Peptide of Crocodile Against Human HCT116 Colon Cancer Xenografts 
Date of Acceptance 4 July 2018 
Journal
     Title of Journal In Vivo 
     Standard ISI 
     Institute of Journal INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH 
     ISBN/ISSN  
     Volume 32 
     Issue
     Month Sep-Oct
     Year of Publication 2018 
     Page 1137-1144 
     Abstract BACKGROUND/AIM: Many antimicrobial peptides have been shown to have anticancer activity against human cancer cell lines. Cationic KT2 peptide, derived from white blood cell extract of Crocodylus siamensis has antibacterial activity and antitumor activity against human cervical cancer cells, but there are no data on the effect of KT2 peptide on tumor growth in vivo. The anticancer activity of KT2 peptide on human colon cancer xenografts was investigated in nude mice. MATERIALS AND METHODS: Tumors in nude mice (BALB/c -nu/nu mice) were induced by subcutaneous injection with HCT116 cells. Twelve days after cancer cell xenograft, mice were treated by intratumoral injection with phosphate-buffered saline or KT2 peptide (25 and 50 mg/kg) once every 2 days for a total of four times and mice were sacrificed at 2 days after the last treatment. RESULTS: KT2 peptide treatment did not lead to significant difference in mouse body weight among groups, but reduced both tumor volume and weight of colon cancer xenografts. Moreover, KT2 peptide increased the expression of apoptotic proteins, such as BCL2-associated X (BAX), cleaved caspase-3, and poly (ADP-ribose) polymerase and reduced that of BCL2 apoptosis regulator in xenograft tumors. CONCLUSION: This finding suggests that KT2 peptide may inhibit tumor growth via apoptosis induction in this mouse model and supports the antitumor ability of KT2 peptide. 
     Keyword Colorectal cancer; KT2 peptide; anticancer activity; apoptosis; xenograft 
Author
587100007-1 Miss PORNSUDA MARAMING [Main Author]
Graduate School Doctoral Degree
597020014-0 Mr. SURACHAI MAIJAROEN
Science Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
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