| Research Title |
Anti-metastatic effect of rice bran hydrolysates on cholangiocarcinoma
cells through suppressed FAK/PI3K/Akt pathway. |
| Date of Distribution |
18 October 2018 |
| Conference |
| Title of the Conference |
The 7th International Conference on Natural Products |
| Organiser |
The Asian Society of Natural Products. |
| Conference Place |
The Hotel Hyundai Gyeongju, Korea |
| Province/State |
Gyeongju, Korea |
| Conference Date |
18 October 2018 |
| To |
20 October 2018 |
| Proceeding Paper |
| Volume |
7 |
| Issue |
1 |
| Page |
98 |
| Editors/edition/publisher |
|
| Abstract |
Cholangiocarcinoma (CCA), cancer of the bile duct, is one of major health concern in Southeast Asian countries and Southern China. The locally advanced and metastatic tumors are causally related to their very poor prognosis. The current chemotherapy is still inefficient. Drugs or dietary supplements have been advocated as chemoprevention of cancer by preventing the seeding and proliferation of tumor cells. Rice bran hydrolysates (RBH) have been shown to possess anti-inflammatory, antioxidant and insulin sensitizing effects. This study aimed to explore effect of RBH on cell migration and invasion of CCA cells. RBH from Tubtim Chumpae rice (RD69) at concentrations of 200-1600 µg/mL strongly suppressed migration of three CCA cell lines, evaluated by wound healing assay and cell invasion by transwell chamber assay in KKU-M156 cells. The effects were associated with suppression of activation of FAK, and PI3K-Akt protein expression. It is concluded that RBH suppress cancer cell migration and invasion in association with inhibition of activation of FAK/PI3K-Akt pathway. Consumption of rice bran may provide health benefit on prevention of cancer.
Acknowledgement: this work was supported by the Agricultural Research Development Agency, Thailand.
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| Author |
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| Peer Review Status |
ไม่มีผู้ประเมินอิสระ |
| Level of Conference |
นานาชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
true |
| Award Title |
The best poster award |
| Type of award |
รางวัลด้านวิชาการ วิชาชีพ |
| Organiser |
The Asian Society of Natural Products. |
| Date of awarding |
20 ตุลาคม 2561 |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
ไทย