| Research Title |
Peak oxygen consumption and metabolic equivalents in female patients with chronic thromboembolic pulmonary hypertension |
| Date of Distribution |
19 December 2018 |
| Conference |
| Title of the Conference |
การประชุมวิชาการสรีรวิทยาสมาคม ครั้งที่ 46 Research and Educational Innovation in Medical Sciences |
| Organiser |
สรีรวิทยาสมาคมแห่งประเทศไทย, ภาควิชาวิทยาศาสตร์การแพทย์พื้นฐาน คณะแพทยศาสตร์วชิรพยาบาล มหาวิทยาลัยนวมินทราธิราช และ ภาควิชาสรีรวิทยา คณะเภสัชศาสตร์ มหาวิทยาลัยมหิดล |
| Conference Place |
โรงแรมโรแมนติก รีสอร์ท แอนด์ สปา เขาใหญ่ |
| Province/State |
นครราชสีมา |
| Conference Date |
19 December 2018 |
| To |
21 December 2018 |
| Proceeding Paper |
| Volume |
1 |
| Issue |
1 |
| Page |
39 |
| Editors/edition/publisher |
|
| Abstract |
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare progressive pulmonary vascular disease. It develops from acute pulmonary embolism (PE). In Thailand, the incidence of CTEPH after acute PE was 5.1%. CTEPH is characterized by chronic emboli and intraluminal fibrous webs or bands in the pulmonary arteries (PA), leading to increased PA pressure and pulmonary vascular resistance (PVR), and consequently dyspnea. Cardiopulmonary exercise testing (CPET) is useful tool to help identify patients with milder abnormalities and CTEPH. Peak oxygen consumption (V’O2 peak) is an important parameter for cardiovascular and respiratory disease prognosis. The aim of this study was to investigate V’O2 peak and metabolic equivalents (METS) in six female patients with CTEPH in comparison to six age-matched healthy subjects. All CTEPH patients had previously been diagnosed with CTEPH that met the criteria for World Health Organization Functional Class (WHO FC) II and III. All patients underwent right heart catheterization. All patients and healthy subjects performed CPET using a treadmill and an incremental protocol until symptom limitation. CTEPH patients had lower average V’O2 peak compared to healthy subjects (651.6 ± 200.8 vs. 1234.4 ± 302.4 ml/min, 38.5 ± 11.4 vs. 67.0 ± 17.1% predicted; 12.4 ± 2.9 vs. 21.8 ± 4.7 ml/min/kg, 44.1 ± 12.2 vs. 77.8 ± 17.9% predicted) (p < 0.01). In addition, CTEPH patients had average peak exercise METS lower compared to healthy subjects (3.4 ± 1.0 vs. 6.5 ± 1.6, 42.1 ± 14.1 vs. 81.4 ± 21.9% predicted) (p < 0.01). In conclusion, the present study demonstrates that CTEPH patients in functional class WHO FC II and III had lower V’O2 peak and METS of approximately 52 to 57% compared to healthy subjects. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Abstract |
| Type of Presentation |
Oral |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
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|
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Publication
Journal Publication
ไทย