2012 ©
             Publication
Journal Publication
Research Title Peak oxygen consumption and metabolic equivalents in female patients with chronic thromboembolic pulmonary hypertension 
Date of Distribution 19 December 2018 
Conference
     Title of the Conference การประชุมวิชาการสรีรวิทยาสมาคม ครั้งที่ 46 Research and Educational Innovation in Medical Sciences 
     Organiser สรีรวิทยาสมาคมแห่งประเทศไทย, ภาควิชาวิทยาศาสตร์การแพทย์พื้นฐาน คณะแพทยศาสตร์วชิรพยาบาล มหาวิทยาลัยนวมินทราธิราช และ ภาควิชาสรีรวิทยา คณะเภสัชศาสตร์ มหาวิทยาลัยมหิดล 
     Conference Place โรงแรมโรแมนติก รีสอร์ท แอนด์ สปา เขาใหญ่ 
     Province/State นครราชสีมา 
     Conference Date 19 December 2018 
     To 21 December 2018 
Proceeding Paper
     Volume
     Issue
     Page 39 
     Editors/edition/publisher  
     Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare progressive pulmonary vascular disease. It develops from acute pulmonary embolism (PE). In Thailand, the incidence of CTEPH after acute PE was 5.1%. CTEPH is characterized by chronic emboli and intraluminal fibrous webs or bands in the pulmonary arteries (PA), leading to increased PA pressure and pulmonary vascular resistance (PVR), and consequently dyspnea. Cardiopulmonary exercise testing (CPET) is useful tool to help identify patients with milder abnormalities and CTEPH. Peak oxygen consumption (V’O2 peak) is an important parameter for cardiovascular and respiratory disease prognosis. The aim of this study was to investigate V’O2 peak and metabolic equivalents (METS) in six female patients with CTEPH in comparison to six age-matched healthy subjects. All CTEPH patients had previously been diagnosed with CTEPH that met the criteria for World Health Organization Functional Class (WHO FC) II and III. All patients underwent right heart catheterization. All patients and healthy subjects performed CPET using a treadmill and an incremental protocol until symptom limitation. CTEPH patients had lower average V’O2 peak compared to healthy subjects (651.6 ± 200.8 vs. 1234.4 ± 302.4 ml/min, 38.5 ± 11.4 vs. 67.0 ± 17.1% predicted; 12.4 ± 2.9 vs. 21.8 ± 4.7 ml/min/kg, 44.1 ± 12.2 vs. 77.8 ± 17.9% predicted) (p < 0.01). In addition, CTEPH patients had average peak exercise METS lower compared to healthy subjects (3.4 ± 1.0 vs. 6.5 ± 1.6, 42.1 ± 14.1 vs. 81.4 ± 21.9% predicted) (p < 0.01). In conclusion, the present study demonstrates that CTEPH patients in functional class WHO FC II and III had lower V’O2 peak and METS of approximately 52 to 57% compared to healthy subjects. 
Author
587070015-7 Mr. SAHACHAT AUEYINGSAK [Main Author]
Medicine Doctoral Degree

Peer Review Status มีผู้ประเมินอิสระ 
Level of Conference ชาติ 
Type of Proceeding Abstract 
Type of Presentation Oral 
Part of thesis true 
Presentation awarding false 
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