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Publication
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| Title of Article |
Structures of isothiocyanates attributed to reactive oxygen species generation and microtubule depolymerization in HepG2 cells |
| Date of Acceptance |
26 February 2018 |
| Journal |
| Title of Journal |
Biomedicine and Pharmacotherapy |
| Standard |
ISI |
| Institute of Journal |
Elsevier |
| ISBN/ISSN |
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| Volume |
2018 |
| Issue |
101 |
| Month |
March |
| Year of Publication |
2019 |
| Page |
698-709 |
| Abstract |
The structure of the isothiocyanates (ITCs)—erucin, sulforaphane, erysolin, sulforaphene, and phenethyl isothiocyanate—were assessed as well as their respective in vitro anticancer activity on the hepatocellular carcinoma cell line HepG2. All of these ITCs induced both apoptotic and necrotic cell death. FTIR analysis indicated
that the ITCs caused changes in cellular components comparable to vinblastine. Despite no observable effect on
DNA, the ITCs all induced generation of intracellular reactive oxygen species (ROS) and suppressed microtubule
polymerization. The variation in sulfur oxidation states and the presence of an aromatic ring on the ITC side
chain affected microtubule depolymerization and intracellular ROS generation, leading to apoptotic and necrotic
cancer cell death. Knowing the influences of structural variations of the ITC side chain would be useful for
selecting the more potent ITCs (i.e., erysolin) for the design and development of effective chemopreventive
agents. |
| Keyword |
Isothiocyanates, Structural variation, Anticancer, Microtubule depolymerization, Reactive oxygen species, HepG2, Apoptosis |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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