| Title of Article |
Rapid Identification of Biofilms Using a Robust Multichannel Polymer Sensor Array |
| Date of Acceptance |
4 March 2019 |
| Journal |
| Title of Journal |
ACS Applied Materials & Interfaces |
| Standard |
SCOPUS |
| Institute of Journal |
American Chemical Society (ACS) |
| ISBN/ISSN |
DOI: 10.1021/acsami.9b00839 |
| Volume |
2019 |
| Issue |
11 |
| Month |
March |
| Year of Publication |
2019 |
| Page |
11202−11208 |
| Abstract |
Infections caused by bacterial biofilms are challenging to diagnose because of the complexity of both the bacteria
and the heterogeneous biofilm matrix. We report here a robust polymer-based sensor array that uses selective interactions
between polymer sensor elements and the biofilm matrix to identify bacteria species. In this array, an appropriate choice of
fluorophore enabled excimer formation and interpolymer FRET, generating six output channels from three polymers. Selective
multivalent interactions of these polymers with the biofilm matrices caused differential changes in fluorescent patterns,
providing a species-based signature of the biofilm. The real-world potential of the platform was further validated through
identification of mixed-species bacterial biofilms and discrimination of biofilms in a mammalian cell-biofilm co-culture wound
model. |
| Keyword |
biofilm infections, biosensor design, fluorescent polymers, bacterial pathogens, multichannel sensor |
| Author |
|
| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Publication
Journal Publication
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