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Publication
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| Title of Article |
Effects of Gold Nanoparticles with Different SurfaceCharges on Cellular Internalization and Cytokine Responsesin Monocytes |
| Date of Acceptance |
13 April 2019 |
| Journal |
| Title of Journal |
BioNanoScience |
| Standard |
SCOPUS |
| Institute of Journal |
Springer US |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
May |
| Year of Publication |
2019 |
| Page |
1-7 |
| Abstract |
Surface modification of gold nanoparticles (AuNPs) affects the interactions between the AuNPs and biological systems. To use AuNPs in biomedical applications, an investigation of how different surface charges of AuNPs affect the internalization mechanisms and functions of monocytes is needed. In this study, U937 cells were exposed to AuNPs with positive (AuNPs+ve) and negative (AuNPs-ve) surface charges. Cellular responses to the AuNPs, including cell uptake pathways, cell activation and cytokine production, were analysed. The results indicated different responses to AuNPs-ve and AuNPs+ve in outcomes including internalization pathways, cell activation and cytokine production levels. Interestingly, the results suggested that AuNPs+ve tended to enter the cells via macropinocytosis and strongly elicited a cellular response of IL-6 production via NF-kB activation, whereas the AuNPs-ve suppressed IL-6 production. Therefore, these results provide essential information for designing nanoparticles and may contribute to possible future nanomedicine applications, such as drug delivery and vaccination. |
| Keyword |
Surface charge, Gold nanoparticles, Cell uptake pathways, Immunity |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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