| Research Title |
Cellular senescence protein p16INK4a of cancer-associated fibroblasts (CAFs) as a prognostic indicator for cholangiocarcinoma patients |
| Date of Distribution |
30 July 2018 |
| Conference |
| Title of the Conference |
การประชุมวิชาการประจำปี ครั้งที่ 34 ประจำปี 2561 Healthcare in Thailand 4.0 |
| Organiser |
คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| Conference Place |
ห้องบรรยาย 1-4 อาคารเตรียมวิทยาศาสตร์คลินิก ชั้น2 คณะแพทยศาสตร์ มหาวิทยาลัยขอนแก่น |
| Province/State |
ขอนแก่น |
| Conference Date |
8 August 2018 |
| To |
10 August 2018 |
| Proceeding Paper |
| Volume |
33 |
| Issue |
5 |
| Page |
108-113 |
| Editors/edition/publisher |
Srinagarind Medical Journal |
| Abstract |
Background and Objective: The tumor suppressor protein p16INK4a (inhibitor of CDK4/6) is a cyclin-dependent kinase inhibitor that plays an important role in cell cycle and cellular senescence. The senescent fibroblast expressing p16INK4a contributes to cancer development and poor prognosis of patients. Therefore, our approach focus on the expression of p16INK4a in cancer associated fibroblasts (CAFs) in cholangiocarcinoma (CCA) patient tissues and its clinicopathological correlation.
Method: The immunohistochemistry and immunofluorescence assays were used to investigate the expression of p16INK4a in forty six samples of CCA tissues. Pearson Chi-square test was used for analyzing of p16INK4a expression and clinicopathological data of CCA patients.
Result: Our results showed that high expression of p16INK4a protein was presented in CAFs surrounding tumor tissues of 24 cases (52.2%) of CCA patients. The positive expression of p16INK4a (p=0.041) was significantly associated with the non-papillary type.
Conclusion: The high expression of p16INK4a was found in CAFs, which referred to senescence-CAFs. Senescent-CAFs was significantly correlated with non-papillary type, which is the unfavorable feature of CCA patients. |
| Author |
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| Peer Review Status |
มีผู้ประเมินอิสระ |
| Level of Conference |
ชาติ |
| Type of Proceeding |
Full paper |
| Type of Presentation |
Poster |
| Part of thesis |
true |
| Presentation awarding |
false |
| Attach file |
|
| Citation |
0
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Publication
Journal Publication
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