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Publication
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| Title of Article |
Spiroaxillarone A, a Symmetric Spirobisnaphthalene with an Original Skeleton from Cyanotis axillaris |
| Date of Acceptance |
26 September 2019 |
| Journal |
| Title of Journal |
Organic Letters |
| Standard |
ISI |
| Institute of Journal |
ACS (American Chemical Society) |
| ISBN/ISSN |
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| Volume |
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| Issue |
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| Month |
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| Year of Publication |
2021 |
| Page |
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| Abstract |
The first representative of a new type of
spirobisnaphthalene with a previously unknown skeletal system, Spiroaxillarone A (1), was isolated from Cyanotis axillaris. The planar structure was determined through analysis of spectroscopic evidence, while electronic circular dichroism (ECD) calculations were used to determine its absolute configuration. The structure of 1 was further
confirmed through X-ray diffraction studies of its tetrabromobenzoate derivative (1a). Spiroaxillarone A exhibited significant antimalarial activity against resistant Plasmodium falciparum (IC50 = 2.32 μM). |
| Keyword |
Spiroaxillarone A, Plasmodium falciparum, Cyanotis axillaris |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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