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Journal Publication
Title of Article Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice 
Date of Acceptance 12 December 2019 
     Title of Journal Molecules 
     Standard ISI 
     Institute of Journal MDPI AG (Basel, Switzerland)  
     ISBN/ISSN doi.org/10.3390/molecules24244587 
     Volume 24 
     Issue 24 
     Month December
     Year of Publication 2019 
     Page 4587 
     Abstract Thai traditional herbal formula ‘’Kleeb Bua Daeng (KBD)’’consists of a 1:1:1 ratio (dry weight) of three medicinal plants: Piper nigrum fruit, the aerial part of Centella asiatica and the petals of Nelumbo nucifera. Oral administration of KBD to unpredictable chronic mild stress (UCMS) mice significantly improved their cognitive function caused by chronic mild stress. Daily administration of KBD significantly decreased the serum corticosterone (CORT) and malondialdehyde (MDA) levels but increased the catalase and superoxide dismutase activities in both frontal cortex and hippocampus. The effects of KBD were similar to those caused by oral administration of vitamin E. HPLC analysis of the KBD extract revealed the presence of piperine, madecassoside, asiaticoside, luteolin-7-O-glucoside, rutin, kaempferol-3-glucoside, quercetin, kaempferol and ferulic acid as major constituents. 
     Keyword Herbal formula; Unpredictable chronic mild stress; Learning and memory behaviors; Oxidative stress; Piper nigrum; Centella asiatica; Nelumbo nucifera 
607150004-9 Miss JUTHAMART MANEENET [Main Author]
Pharmaceutical Sciences Doctoral Degree

Reviewing Status มีผู้ประเมินอิสระ 
Status ตีพิมพ์แล้ว 
Level of Publication นานาชาติ 
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