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Publication
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| Title of Article |
Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice |
| Date of Acceptance |
12 December 2019 |
| Journal |
| Title of Journal |
Molecules |
| Standard |
ISI |
| Institute of Journal |
MDPI AG (Basel, Switzerland) |
| ISBN/ISSN |
doi.org/10.3390/molecules24244587 |
| Volume |
24 |
| Issue |
24 |
| Month |
December |
| Year of Publication |
2019 |
| Page |
4587 |
| Abstract |
Thai traditional herbal formula ‘’Kleeb Bua Daeng (KBD)’’consists of a 1:1:1 ratio (dry weight) of three medicinal plants: Piper nigrum fruit, the aerial part of Centella asiatica and the petals of Nelumbo nucifera. Oral administration of KBD to unpredictable chronic mild stress (UCMS) mice significantly improved their cognitive function caused by chronic mild stress. Daily administration of KBD significantly decreased the serum corticosterone (CORT) and malondialdehyde (MDA) levels but increased the catalase and superoxide dismutase activities in both frontal cortex and hippocampus. The effects of KBD were similar to those caused by oral administration of vitamin E. HPLC analysis of the KBD extract revealed the presence of piperine, madecassoside, asiaticoside, luteolin-7-O-glucoside, rutin, kaempferol-3-glucoside, quercetin, kaempferol and ferulic acid as major constituents. |
| Keyword |
Herbal formula; Unpredictable chronic mild stress; Learning and memory behaviors; Oxidative stress; Piper nigrum; Centella asiatica; Nelumbo nucifera |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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