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Publication
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| Title of Article |
Antimetabolic Syndrome Effect of Phytosome Containing the Combined Extracts of Mulberry and Ginger in an Animal Model of Metabolic Syndrome |
| Date of Acceptance |
21 September 2019 |
| Journal |
| Title of Journal |
Oxidative Medicine and Cellular Longevity |
| Standard |
ISI |
| Institute of Journal |
Hindawi Publishing Corporation |
| ISBN/ISSN |
1942-0994 |
| Volume |
2019 |
| Issue |
2019 |
| Month |
November |
| Year of Publication |
2019 |
| Page |
19 pages |
| Abstract |
Due to the antimetabolic syndrome effect of mulberry and ginger together with the advantages of the synergistic effect and
phytosome encapsulation technique, we hypothesized that phytosome containing the combined extracts of mulberry and ginger
(PMG) should be able to manage MetS. PMG was developed and assessed the phenolic content and biological activities
associated with the pathophysiology of MetS. The antimetabolic syndrome effect and the possible underlying mechanisms in the
animal model of MetS were also assessed. Male Wistar rats induced MetS by subjecting to a 16-week high-carbohydrate high-fat
diet. MetS rats were orally given PMG at doses of 50, 100, and 200 mg/kg for 21 days. They were determined metabolic
parameter changes in serum, histomorphology changes of adipose tissue, the inflammatory cytokines such as IL-6 and TNF-α,
oxidative stress status, PPAR-γ, and HDAC3 in adipose tissue. Our in vitro data showed that PMG increased phenolic contents
and biological activities. PMG significantly improved MetS parameters including body weight gain, lipid profiles, plasma
glucose, HOMA-IR, and ACE. In addition, the density and size of adipocyte, adiposity index, and weights of adipose tissues
were also improved. Moreover, the decrease in TNF-αand IL-6, oxidative stress status, and HDAC3 expression together with
the increase in PPAR-γexpression in adipose tissue was also observed. These data suggest that PMG exhibit antimetabolic
syndrome and the possible underlying mechanism may be associated partly with the modulation effect on HDAC3, PPAR-γ,
and adipose tissue. In addition, PMG also improves oxidative stress and inflammation in MetS. Therefore, PMG can be served
as the potential supplement to manage MetS. However, a clinical trial study is essential to confirm this health benefit. |
| Keyword |
Ginger, Metabolic syndrome, Mulberry, Phytosome |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ตีพิมพ์แล้ว |
| Level of Publication |
นานาชาติ |
| citation |
true |
| Part of thesis |
true |
| Attach file |
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| Citation |
0
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Journal Publication
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