Title of Article |
Effect of Lisinopril on Left Ventricular and Vascular Function in Nitric Oxide-Deficient Rats (ผลของลิซิโนพริลต่อการทำงานของหัวใจห้องล่างซ้ายและหลอดเลือดในหนูที่มีภาวะพร่องไนตริกออกไซด์) |
Date of Acceptance |
20 February 2020 |
Journal |
Title of Journal |
ศรีนครินทร์เวชสาร (Srinagarind Medical Journal) |
Standard |
TCI |
Institute of Journal |
Srinagarind Medical Journal,Faculty of Medicine, Khon Kaen University |
ISBN/ISSN |
0857 3123 |
Volume |
35 |
Issue |
3 |
Month |
พฤษภาคม-มิุถนายน |
Year of Publication |
2020 |
Page |
- |
Abstract |
Background and Objective: Lisinopril, angiotensin-converting enzyme inhibitors (ACEIs), is widely used to treat hypertension and heart failure. This study investigated whether lisinopril could prevent Nω-Nitrol-arginine methyl ester (L-NAME)-induced hypertension, left ventricular (LV) and vascular dysfunction in rats.
Methods: Male Sprague-Dawley rats were treated with L-NAME (40 mg/kg/day) in drinking water only or together with lisinopril (2.5 mg/kg/day) for five weeks while control rats received distilled water (n=5). Blood pressure and cardiac function were measured. Aortic rings were isolated for vascular function test.
Results: Rats treated with L-NAME had high blood pressure and impairment of cardiac function and acetylcholine (ACh)-induced vasorelaxation in isolated aortic rings. Vascular response to sodium nitroprusside (SNP) did not differ among groups. Interestingly, lisinopril significantly prevented L-NAME-induced hypertension and alleviated L-NAME-induced cardiac and vascular dysfunction (p<0.05).
Conclusion: These findings suggested that lisinopril prevented the development of hypertension and partially prevented cardiac and vascular endothelial dysfunction induced by L-NAME.
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Keyword |
Lisinopril, L-NAME-induced hypertensive rats, Cardiac and vascular dysfunction |
Author |
|
Reviewing Status |
มีผู้ประเมินอิสระ |
Status |
ได้รับการตอบรับให้ตีพิมพ์ |
Level of Publication |
ชาติ |
citation |
false |
Part of thesis |
true |
ใช้สำหรับสำเร็จการศึกษา |
ไม่เป็น |
Attach file |
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Citation |
4
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