| Title of Article |
Effect of Lisinopril on Left Ventricular and Vascular Function in Nitric Oxide-Deficient Rats (ผลของลิซิโนพริลต่อการทำงานของหัวใจห้องล่างซ้ายและหลอดเลือดในหนูที่มีภาวะพร่องไนตริกออกไซด์) |
| Date of Acceptance |
20 February 2020 |
| Journal |
| Title of Journal |
ศรีนครินทร์เวชสาร (Srinagarind Medical Journal) |
| Standard |
TCI |
| Institute of Journal |
Srinagarind Medical Journal,Faculty of Medicine, Khon Kaen University |
| ISBN/ISSN |
0857 3123 |
| Volume |
35 |
| Issue |
3 |
| Month |
พฤษภาคม-มิุถนายน |
| Year of Publication |
2020 |
| Page |
- |
| Abstract |
Background and Objective: Lisinopril, angiotensin-converting enzyme inhibitors (ACEIs), is widely used to treat hypertension and heart failure. This study investigated whether lisinopril could prevent Nω-Nitrol-arginine methyl ester (L-NAME)-induced hypertension, left ventricular (LV) and vascular dysfunction in rats.
Methods: Male Sprague-Dawley rats were treated with L-NAME (40 mg/kg/day) in drinking water only or together with lisinopril (2.5 mg/kg/day) for five weeks while control rats received distilled water (n=5). Blood pressure and cardiac function were measured. Aortic rings were isolated for vascular function test.
Results: Rats treated with L-NAME had high blood pressure and impairment of cardiac function and acetylcholine (ACh)-induced vasorelaxation in isolated aortic rings. Vascular response to sodium nitroprusside (SNP) did not differ among groups. Interestingly, lisinopril significantly prevented L-NAME-induced hypertension and alleviated L-NAME-induced cardiac and vascular dysfunction (p<0.05).
Conclusion: These findings suggested that lisinopril prevented the development of hypertension and partially prevented cardiac and vascular endothelial dysfunction induced by L-NAME.
|
| Keyword |
Lisinopril, L-NAME-induced hypertensive rats, Cardiac and vascular dysfunction |
| Author |
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| Reviewing Status |
มีผู้ประเมินอิสระ |
| Status |
ได้รับการตอบรับให้ตีพิมพ์ |
| Level of Publication |
ชาติ |
| citation |
false |
| Part of thesis |
true |
| Attach file |
|
| Citation |
4
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Publication
Journal Publication
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